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TAT-modified tetramethylpyrazine-loaded nanoparticles for targeted treatment of spinal cord injuryJian Li a cJun Wei aYujie Wan aXingjie Du aXiaosheng Bai aChunhong Li aYan Lin aZhongbing Liu aMeiling Zhou bZhirong Zhong aJournal of Controlled Release...
c PC12 cells were cotransfected (1/1) with Tat-FLAG and a Gag mutant or an empty vector as indicated before assaying Tat palmitoylation using ABE. Gag-MA-22/27A and Gag-CA-G89V are mutated within their PI(4,5)P2- and CypA-binding motif, respectively. d Jurkat T-cells were ...
this 7SK snRNP also contains the 7SK snRNA that acts as a molecular scaffold to hold the complex together and the HEXIM protein, which functions as an inhibitor of CDK917,22,23,24,25. Within the 7SK snRNP, the-
WU Yong-Hong 展开 摘要: The TAT protein transduction peptide rich in basic amino acids,encoded by human immunodeficiency virus type 1,was a member of the protein transduction domain family.It has been widely known that the full-length TAT peptide and the core domain(YGRKKRRQRRR)play importa...
Al segle x el territori de Bratislava (el que després seria el comtat de Pressburg) passà a ser part d'Hongria (que s'anomenava Regne d'Hongria des de l'any 1000) i esdevingué una ciutat clau per a l'economia i centre administratiu a la frontera del regne. 在10世纪,布拉迪斯...
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HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. Mass spectrometry analysis showed pr
Furthermore, when utilizing an in vitro transcription assay, as well as a Tat mutant virus, we found that ectopic expression of only wild-type Tat in the presence of p300, and not a lysine 41 Tat mutant, could activate HIV-1 chromatin DNA, as evidenced by the absence of HIV-1 virion ...
Li, HongD. Wade, JohnLambert, PaulKumar, AjitKashanchi, FatahCurrent HIV ResearchPumfery, A., L. Deng, A. Maddukuri, C. de la Fuente, H. Li, J. D. Wade, P. Lambert, A. Kumar and F. Kashanchi (2003). "Chromatin remodeling and modification during HIV-1 Tat-activated ...