There is as-yet incomplete information regarding the full-range of genetic variants of most GPCRs, including orphan GPCRs, and thus this is likely to remain an area of active research with potential clinical importance. In addition, two aspects of such variants that have not yet been well ...
In the presence of the chelating triad, these HID analogues may either compete for the DNA polymerase active site or bind at an unknown site of RT and disturb both the DNA polymerase and RNase H activities. Docking calculations suggested favorable binding of the compounds at the HIV RNase H ...
where they have been found to be more effective at inhibiting tumor growth and inducing apoptosis in tumor cells in mice mode. PRIMA-1 has been found to be implicated in reactivating mutant p53 by covalent binding of MQ per se, therefore, can serve as an approach for designing...
Uterine cervical and endometrial cancers are the two most common gynecological malignancies. As demonstrated in other types of solid malignancies, an increased number of circulating or tumor-infiltrating myeloid-derived suppressor cells (MDSCs) have also been observed in uterine cervical and endometrial ...