Also, as mutations are a necessary component of malignancy, such a method is potentially applicable to all tumors. I propose a method by which several recently developed techniques can be utilized in a novel way to accomplish the goal of directly targeting mutations for cancer detection and ...
Inactivating mutations in the tumour suppressor geneTP53are frequent in cancer. This Review provides a critical overview of reactivating p53 as a therapeutic strategy, describing preclinical and clinical compounds that re-establish the functions of wild-
Through this exploration of Himalayan flora, this review seeks to illuminate potential breakthroughs in lung cancer management using natural compounds. The amalgamation of Himalayan plant-derived compounds with cautiously designed combined therapeutic approaches such as nanocarrier-mediated drug delivery and syn...
Research on direct inhibition of KRAS mutations date back to the discovery of RAS-activated mutations in human cancer cells in the 1980s when RAS-activated mutations were found in human cancer cells. However, some studies have found that KRAS mutants can be targeted by heterogeneous sites, to ...
Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis t
Therefore, dozens of MTH1 inhibitors have been developed with the aim of suppressing cancer growth by accumulating oxidative damage in cancer cells. While several inhibitors were indeed confirmed to be effective, some inhibitors failed to kill cancer cells, complicating MTH1 as a viable target for ...
One view is that CSCs have the same characteristics as stem cells and, therefore, may be derived from the gene mutations of normal stem cells. Another idea is that they are dedifferentiated from cancer cells, including cancer cell lines and patient tumor tissues [15]. Recent studies have ...
The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential
targetEGFRmutations. Koichi Goto, chief of the Department of Thoracic Oncology at the National Cancer Center Hospital East, Chiba, Japan, and principal investigator of LC-SCRUM-Asia says: “Since these rare mutations occur in less than 5% of lung adenocarcinoma, it’s very difficult to detect ...
Transcription factor activity is altered in numerous cancer types via various direct mechanisms including chromosomal translocations, gene amplification or deletion, point mutations and alteration of expression, as well as indirectly through non-coding DNA mutations that affect transcription factor binding. ...