Targeting heat shock pro- teins in prostate cancer. Curr Med Chem 2013;20:2731-40.Hessenkemper W, Baniahmad A (2013) Targeting heat shock proteins in prostate cancer. Curr Med Chem. :Hessenkemper W, Baniahmad A. Targeting heat shock proteins in prostate cancer. Curr Med Chem 2013;20:...
Next article in issue peptide cancer heat shock proteins imaging 99mTcCited by (0)R.W. and J.Z. contributed to conceptualization; Y.D., Z.C., P.Y., and C.Z. contributed to methodology; Y.D. contributed to statistical analysis; Y.D. contributed to writing; X.C., X.Y. and M.L...
ATP is secreted, and as the cell membrane becomes permeabilized, there is the release and exposure of heat shock proteins (HSP70 and 90) and the nuclear protein HMGB1. Once on the outside of the cell membrane, they bind to CD91, P2RX7, and TLR4. ATP and the heat shock proteins ...
(2016). Heat shock proteins promote Cancer: It’s a Protection Racket. Trends in Biochemical Sciences, 41(4), 311–323. https://doi.org/10.1016/j.tibs.2016.01.003. Article CAS PubMed PubMed Central Google Scholar Bhartiya, D., Sharma, N., Dutta, S., Kumar, P., Tripathi, A., ...
Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics Novel approaches towards cancer therapy are urgently needed. One approach might be to target ion channels mediating Ca2+entry because of the critical roles... HJ Gaunt,NS Vasudev,DJ Beech - 《European Biophysic...
Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment Rapidly growing tumours in vivo often outgrow their surrounding available blood supply, subjecting themselves to a severely hypoxic microenvironment. Understanding how tumour cells ...
The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein fo
In early work, inhibitors of chaperone protein heat shock protein 90 (HSP90) can induce degradation of its client proteins, including many known oncoproteins, in cancer cells. However, although more than 30 of HSP90 inhibitors have been in clinical trials during the past two decades, none have...
Focal adhesion kinase (FAK) is an integrin-associated protein tyrosine kinase that is frequently overexpressed in advanced human cancers. Recent studies have demonstrated that aside from FAK’s catalytic activity in cancer cells, its cellular localization is also critical for regulating the transcription...
Dozens of lethal signal transduction pathways converge on mitochondria to cause the permeabilization of the mitochondrial outer membrane, leading to the cytosolic release of pro-apoptotic proteins and to the impairment of the bioenergetic functions of mitochondria. The mitochondrial metabolism of cancer ...