Heat shock proteins (HSP) play multiple roles in cellular physiology and pathology depending on a wide variety of factors including its relative location within the cell (intracellular, plasma membrane or extracellular milieu), the age of the cell or whether it has undergone neoplastic transformation...
Heat shock proteins (HSPs) exist ubiquitously across all species and function as chaperones stabilizing and delivering peptides. Tumor-derived HSP-peptide complex has been known to induce immunity against the original tumor in preclinical studies. HSP-based vaccines work across tumor types and bypass ...
Development of cancer vaccines using autologous and recombinant high molecular weight stress proteins High molecular weight heat shock proteins (HSPs), hsp110 and grp170, derived from cancer cells have been previously shown to elicit tumor-specific immunity... XY Wang,MH Manjili,J Park,... - 《...
degradation of damaged proteins, HSPs frequently act as chaperones for proteins withinthe cell. They have been found to activate immune responses, HSP90 and HSP70 HSP groups play an active role in alerting immune cells to potential threats such as the presence of cancer or invasion by pathogens....
The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide range of tumors and are closely associated with a poor prognosis and resistance to therapy. The increased transcription of HSPs in tumor cells is due to loss of p53 function and to higher expression...
The involvement of heat shock proteins in immune response is categorized into four distinct paradigms. In the First Paradigm, HSP derived from foreign organisms act as classical foreign antigens, and they elicit immune response to the non-conserved HSP epitopes. The Second Paradigm refers to instanc...
Do heat shock proteins have a role in breast cancer? It is clear therefore that hsps are overexpressed in patients with malignant tumours compared with healthy controls and this overexpression does show some ... S Conroy,D Latchman - 《Br J Cancer》 被引量: 302发表: 1996年 Immunotherapy for...
Of the PIs tested, cancer cells, were most sensitive to MG-132 and least sensitive to LLM. MG-132 also showed a 10-fold differential sensitivity between estrogen receptor positive, (ER+) MCF-7 cells and negative cells, (ER-) MDA-MB-231. Induction of heat shock proteins, gp96 and ...
Background: Heat shock proteins (HSPs) are predominant molecular chaperones which are actively involved in the protein folding; which is essential in protecting the structure and functioning of proteins during various stress conditions. Though HSPs have important physiological roles, they have been well...