Glioblastoma multiforme (GBM) is the most aggressive human brain tumor. Standard of care includes surgical resection, radiation therapy, and concomitant adjuvant chemotherapy with temozolomide (TMZ) which can only modestly improve median survival. Resistance to treatment is often associated with a ...
Malignant ependymoma, the third most common brain tumor in children, is normally treated with a combination of surgery and radiotherapy, sometimes with the addition of chemotherapy. SUGGESTED for you A radiation dose of 59.4 Gy is currently recommended for pediatric cases worldwide. However, the sub...
The median overall survival of patients with glioblastoma (GBM) is only 14.6 months after current multimodal treatment–aggressive surgical resection followed by concurrent or sequential radiation and temozolomide chemotherapies3. One reason why poor prognosis and rapid recurrence are associated with this ...
Based on the data from the Central Brain Tumor Registry of the United States, the overall incidence of malignant brain tumors in patients of all ages decreased by about 0.8% per year from 2008 to 2017,12while it has been elevated in non-malignant tumors.13The brain tumors have a total inc...
Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity Open access19 February 2022 Introduction Over half of cancer patients undergo radiation therapy (RT). RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy.1...
and precision, various non-invasive strategies to overcome BBB have been exploited. These strategies include BBB penetration via passive transcytosis, intranasal administration, ligands conjugation, membrane coating, and the BBB disruption using light, focused ultrasound, biochemical reagents, and radiation....
Gliomas are the most common primary malignant brain tumour [1]. The current standard of care for gliomas includes a combination of surgery, chemotherapy, and radiation therapy, depending on the specific type of tumour. However, even with current treatments, the median survival times for patients ...
All patients were treated at first recurrence within the radiation field and were not eligible for resection after neurosurgeons’ evaluation. Patients were informed that re-resection, re-irradiation, systemic therapy, and best supportive care were the treatment options and chose to receive the ...
When visible light radiation interacts with tissues, reflection, refraction, scattering, and absorption phenomena contribute to the overall reduction in light intensity. As the tissue thickens, the rapid depletion of the light dose causes an ineffective treatment [1,4]. Lower absorption and reduced ...
Compared with whole-brain radiotherapy, WBRT combined with local tumor intensity modulated radiation therapy (IMRT) is currently the primary treatment option for cancer brain metastases [19]. Stereotactic radiotherapy (SRT) uses modern imaging technology to correctly find the target area, accurately ...