Systemic immune monitoring is a crucial clinical tool for disease early diagnosis, prognosis and treatment planning by quantitative analysis of immune cells. However, conventional immune monitoring using flow cytometry faces huge challenges in large-scal
The ORR of the FOLFOX4-placebo group was 9.1%, which included only 1 case of CR, and the DCR was 30.9%. The radiological images of two HCC patients with EHM who achieved CR in the FOLFOX4-ATRA group are shown in Figs. 3 and 4. The first patient (supplementary Fig. S1) suffered ...
In some case series, a small proportion of patients reported positive RF and ANA. Thus, although AOSD is considered as a seronegative disorder (as per the Yamaguchi criteria), it should also be taken into consideration in seropositive patients with typical clinical presentation and other compatible...
Here we review the list of TRPV1 agonists undergoing clinical trials for chronic pain management, and discuss new indications, formulations or combination therapies being explored for capsaicin. While the analgesic pharmacopeia for chronic pain patients is ancient and poorly effective, modern TRPV1-...
Furthermore, dose increases should only be implemented in case of acceptable toxicity and patients with low exposure and considerable toxicity should be switched to another treatment option. Of note, while TDM might be crucial for agents with a narrow therapeutic window (i.e. pazopanib, sunitinib)...
"Water rights in terms of allocation in most of the farmers managed irrigation system are closely related and proportional to the landholding size of farmers. Unlike such common cases, water allocation in Chherlung irrigation system in Palpa district in mid hill of Nepal is based on the marketab...
In each case, ectopic expression of these microRNAs reduced channel expression and inhibited proliferation of the cancer cells. KCNMA1 gene is a direct target of miR-17-5p and genetic and pharmacological inhibition of its protein, KCa1.1 modulates migration in MPM cells...
225 The first resistance case to TRK inhibition was discovered in a colorectal cancer patient treated with entrectinib, and two acquired resistance mutations, TRKA G595R and TRKA G667C, were detected in the plasma cfDNA of this patient.240 Several other resistant mutations were subsequently ...
Effectively killing pathogenic bacteria is key for the treatment of sepsis. Although various anti-infective drugs have been used for the treatment of sepsis, the therapeutic effect is largely limited by the lack of a specific bacterium-targeting delivery
In a case report, a 45-year-old woman infected by SARS-CoV-2 initially received hydroxychloroquine (400 mg twice daily) and anticoagulant nadroparin (4 mg once daily); as her condition worsened, she was intubated. On the 9th day after the onset of symptoms, she was given human recombinant...