Gibiansky L, Gibiansky E. Target-mediated drug disposition model for drugs that bind to more than one target. J Pharma- cokinet Pharmacodyn. 2010;37(4):323-46. doi:10.1007/s10928- 010-9163-3.L. Gibiansky and E. Gibiansky, Target-mediated drug disposition model for drugs that bind to ...
1993年,Gerhard Levy首先提出了靶点介导的药物处置(target mediated drug disposition,TMDD)理论[6]。TMDD模型应用房室模型的方法描述单抗线性消除和分布特征,并通过与靶点的结合和解离常数描述单抗的非线性特征部分。与采用典型的米氏( Michaelis-Menten)方式描述非线性特征相较,TMDD模型描述了抗体与靶点的相互作用,帮助我...
Target-mediated drug disposition model for drugs with N > 2 binding sites that bind to a target with one binding site. J Pharmacokinet Pharmacodyn 51, 703–720 (2024). https://doi.org/10.1007/s10928-024-09917-8 Download citation Received29 January 2024 Accepted27 March 2024 Published19...
Target-mediated drug disposition happens when the binding of the drug to the target influences the drugs distribution and elimination. This is in particular often the case forbiologics(see section Examples of molecules), such as monoclonal antibodies for instance (for a review, see for instanceDos...
Target-mediated drug disposition can manifest to affect the pharmacokinetics of a fragment crystallizable (Fc)-fused cytokine when the nontarget-mediated clearance of the cytokine is decreased due to neonatal Fc receptor-mediated recycling and molecular weight increases that reduce the renal clearance. ...
target‐mediated drug disposition modeltherapeutic proteinsMany therapeutic proteins are designed to be highly specific and act by binding to a specific target. Binding to the target may strongly influence or even dominate pharmacokinetic (PK) and pharmacodynamic (PD) properties of these drugs, ...
Target-mediated drug disposition (TMDD) is frequently reported for therapeutic monoclonal antibodies and is linked to the high affinity and high specificity of antibody molecules for their target. Understanding TMDD of a monoclonal antibody should go beyond the empirical description of its non-linear PK...
(0) 1.9K Downloads Updated7 Apr 2022 View License Share Download This is the SimBiology implementation of generic Target-Mediated Drug Disposition model (TMDD) presented in [1]. Reference: [1] Mager DE and Jusko WJ (2001) General pharmacokinetic model for drugs exhibiting target-med...
인용 양식 Fulden Buyukozturk (2025).SimBiology model for Target-Mediated Drug Disposition (TMDD)(https://www.mathworks.com/matlabcentral/fileexchange/32926-simbiology-model-for-target-mediated-drug-disposition-tmdd), MATLAB Central File Exchange. 검색 날짜:2025/2/19. ...
Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition. Purpose The aim of this study is to derive and evaluate an equilibrium model of a previously developed general pharmacokinetic model for drugs exhibiting ... DE Mager,W Krzyzanski - 《Pharmaceutical Research...