Target-mediated drug disposition model for drugs that bind to more than one target. J Pharmacokinet Pharmacodyn. 2010;37(4):323–46.Gibiansky L, Gibiansky E. Target-mediated drug disposition model for drugs that bind to more than one target. J Pharmacokinet Pharmacodyn 2010 Aug; 37 (4): ...
Gibiansky L, Gibiansky E (2017) Target-mediated drug disposition model for drugs with two binding sites that bind to a target with one binding site. J Pharmacokinet Pharmacodyn. https://doi.org/10.1007/s10928-017-9533-1 Article PubMed Google Scholar Kuester K, Kloft C: Pharmacokinetics of...
在单克隆抗体的代谢中,其与靶点结合形成单抗靶点复合物进行消除是单抗代谢的重要特征之一。1993年,Gerhard Levy首先提出了靶点介导的药物处置(target mediated drug disposition,TMDD)理论[6]。TMDD模型应用房室模型的方法描述单抗线性消除和分布特征,并通过与靶点的结合和解离常数描述单抗的非线性特征部分。与采用典型的米...
Target-mediated drug disposition can manifest to affect the pharmacokinetics of a fragment crystallizable (Fc)-fused cytokine when the nontarget-mediated clearance of the cytokine is decreased due to neonatal Fc receptor-mediated recycling and molecular weight increases that reduce the renal clearance. ...
Levy, G. (1994). Pharmacologic target-mediated drug disposition. Clinical Pharmacology Therapeutics, 56(3), 248–252. Levy describes the TMDD in the following way: “a considerably larger fraction of the dose of these high-affinity compounds is bound to target sites, enough so that this intera...
Target-mediated drug disposition (TMDD) is frequently reported for therapeutic monoclonal antibodies and is linked to the high affinity and high specificity of antibody molecules for their target. Understanding TMDD of a monoclonal antibody should go beyond the empirical description of its non-linear PK...
Target-mediated drug disposition model: approximations, identifiability of model parameters and applications to the population pharmacokinetic-pharmacodyna... Models for drugs exhibiting target-mediated drug disposition (TMDD) describe biological processes in which drug-target binding significantly influences bot...
Version 1.0.1.2(267 KB) byFulden Buyukozturk SimBiology implementation of the Target-Mediated Drug Disposition (TMDD) model Follow 0.0 (0) 1.9K Downloads Updated7 Apr 2022 View License Share Download This is the SimBiology implementation of generic Target-Mediated Drug Disposition model (...
Fulden Buyukozturk (2025).SimBiology model for Target-Mediated Drug Disposition (TMDD)(https://www.mathworks.com/matlabcentral/fileexchange/32926-simbiology-model-for-target-mediated-drug-disposition-tmdd), MATLAB Central File Exchange. 검색 날짜:2025/2/19. ...
target‐mediated drug disposition modeltherapeutic proteinsMany therapeutic proteins are designed to be highly specific and act by binding to a specific target. Binding to the target may strongly influence or even dominate pharmacokinetic (PK) and pharmacodynamic (PD) properties of these drugs, ...