GHR is a target for inducible metalloprotease-mediated cleavage in its perimembranous extracellular domain, a process that liberates the extracellular domain as the soluble GH-binding protein and leaves behind a cell-associated GHR remnant protein containing the transmembrane and cytoplasmic domains. GHR...
The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are highly specialized cells. They function as a critical size and... SJ Shankland - 《Kidney International》 被引量: 1570发表: 2006年 From the periphery of the glomerular capillary wall toward the center of di...
Cell 56, 997–1010 (1989). 14. Erdman, S. E. & Burtis, K. C. The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain. EMBO J 12, 527–535 (1993). 15. Erdman, S. E., Chen, H. J. & Burtis, K. C. Functional and genetic characterization of the...
A Mammalian Target of Rapamycin Inhibitor (mTOR) is a protein kinase that regulates cell growth, proliferation, and differentiation by blocking cell proliferation and disrupting the binding of growth factors to their receptors, thus playing a role in cancer treatment and immunosuppression. ...
Low picomolar doses of gamma3-MSH increase [Ca(2+)](i) in the growth hormone (GH)- and prolactin (PRL)-secreting GH3 cell line. gamma2-MSH and alpha-MSH display a similar effect. SHU9119 does not affect the gamma3-MSH-induced [Ca(2+)](i) response. MTII, a potent synthetic ...
Mode of action of pituitary growth hormone on target cells Cell-type-specific signatures of microRNAs on target mRNA expression. Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Targ...
IC(50) values of LHRH-PE40, which caused 50% inhibition of tumor cell growth were evaluated by MTT assay. The target cells were exposed to LHRH-PE40 and its cytotoxicity was analyzed by scanning and transmission electron microscopies, agarose gel electrophoresis, and flow cytometry. RESULTS: ...
Target of rapamycin (TOR) acts as an important regulator of cell growth, development and stress responses in most examined diploid eukaryotes. However, little is known about TOR in tetraploid species such as cotton. Here, we show that TORC1-S6K-RPS6, the major signaling components, are conserv...
Both AT1 and AT2 are key components of a hormone system that helps regulate blood pressure and sodium levels in the blood. They are known as "membrane proteins" because they straddle the plasma membranes of cells, where they receive signals from hormones outside the cell and pass them along ...
Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Retrovirology 2006;3:22. Article CAS PubMed PubMed Central Google Scholar Turkson J, Bowman T, Garcia R, Calden...