Cancer-derived supermeres increase lactate secretion, transfer cetuximab resistance and decrease hepatic lipids and glycogen in vivo. This study identifies a distinct functional nanoparticle replete with potent
As introduced above, nearly all of the major BR signaling components were originally identified in the model plant Arabidopsis (Arabidopsis thaliana). However, phylogenetic studies indicate that these genes are highly conserved among monocots and dicots1, suggesting that the classical BR signaling is co...
Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic...
What are the major types of chemicals which can act as hormones? What hormones and regulating hormones are in the pituitary-hypothalamus loop? What are the functions of each type of hormone produced by the adrenal cortex? Name the two ...
pathway in hormone signaling. In addition, recent work confirms that hormone signaling interacts at multiple levels during plant growth and development. In the future, a major challenge will be to understand how the information conveyed by these simple compounds is integrated during plant growth. ...
According to previous studies about flowering, MADS-box genes encoding proteins involved in flower- ing identity determination are major targets of FLOW- ERING LOCUS T and it was speculated that StMADS genes were downstream targets of tuberigen StSP6A. Therefore, the whole-genome microarray data ...
The viral genome has been sequenced [12], [13] and in the meantime a growing part of its proteins has been characterized [14], [15], so that three-dimensional molecular structures have become already available as targets for the ongoing drug research [16], [17] and development of ...
The enterochromaffin (EC) cell is an enteroendocrine cell subtype that represents one of the major proposed epithelial chemosensors. Although relatively rare (<1% of total intestinal epithelia), these unique cells produce >90% of the body’s serotonin and have been suggested to affect a variety of...
Concerning the response to therapy of BC subtypes, Luminal B responds better to neoadjuvant chemotherapy, but is less responsive to hormonal therapy than Luminal A [9]. Potential targets in Luminal B are insulin-like growth factor 1 (IGF-1) signalling, fibroblast growth factor (FGF) signalling,...
Salinity and drought are one of the major environmental stresses that limit worldwide plant growth and crop production. Plants have evolved multiple sophisticated strategies to cope with the adverse stresses via perceiving the stress signal and transmitting the information through a variety of signal tra...