What are the major types of chemicals which can act as hormones? What hormones and regulating hormones are in the pituitary-hypothalamus loop? What are the functions of each type of hormone produced by the adrenal cortex? Name the two ...
Pivotal in many ways for human health, the control of adult bone mass is governed by complex, incompletely understood crosstalk namely between mesenchymal stem cells, osteoblasts and osteoclasts. The SOX4, SOX11 and SOX12 (SOXC) transcription factors wer
The OSE replenishing mechanism post ovulation remains unclear. Here we report that the expression of Protein C Receptor (Procr) marks a progenitor population in adult mice that is responsible for OSE repair post ovulation. Procr+ cells are the major cell source for OSE repair. The mechanism...
As introduced above, nearly all of the major BR signaling components were originally identified in the model plant Arabidopsis (Arabidopsis thaliana). However, phylogenetic studies indicate that these genes are highly conserved among monocots and dicots1, suggesting that the classical BR signaling is co...
Role of the Growth Hormone/Insulin-like Growth Factor-1 Paracrine Axis in Rheumatic Diseases Hypothalamic-pituitary axis abnormalities have been associated with systemic disturbances in several rheumatic diseases. Longitudinal analysis of erythrocy... CW Denko,CJ Malemud - 《Semin Arthritis Rheum》 被引...
(LOX2.1) is located in chloroplasts within leaves and is considered to be the major form that provides the substrate for oxylipin (like jasmonate) biosynthesis (Wasternack and Feussner2018). LOX2-1 from mesophyll cells was found to be an important factor in stomatal closure inA.thaliana(Sun ...
1 MITF binds the canonical E-box promoter sequence CACGTG as well as the non-palindromic sequence CACATG.2, 3 The three major pigmentation enzymes tyrosinase, TYRP1, and DCT all contain the MITF consensus binding site in their promoters and are thought to be transcriptional targets of MITF.2...
Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimic...
Regulatory T cells (Tregs) are critically involved in neovascularization, an important compensatory mechanism in peripheral artery disease. The contribution of G protein coupled receptor 174 (GPR174), which is a regulator of Treg function and development
(Fig.7c, Supplementary Data5). In addition, we found BCs were the major immune cell population in the thyroid tissues, and the ratio of CD8+TCs to CD4+TCs increased slightly in thyroid tissues compared to that in PBMCs, but NK cells decreased significantly (Fig.7d). While CD4+TCs in ...