A glutamine-based single α-helix scaffold to target globular proteins Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B. Kragelund, Jesús García, ...
a Heterologous expression of targeting proteins by employing bacteriophage origin RBPs and CBDs. b Development of two distinct nanodelivery systems by employing heterologous expressed RBP and CBD as targeting devices: lipid-coated UPSNs (LUN) bearing RBPs (LUN@RBP) and CBDs modified UPSNs (UPSN...
Koopman, B. et al. Actionability of on-target ALK resistance mutations in patients with non-small cell lung cancer: local experience and review of the literature. Clin. Lung Cancer 23, e104–e115 (2021). Article PubMed Google Scholar Shiba-Ishii, A. et al. Analysis of lorlatinib anal...
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that starts
The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target. J. Biol. Chem. 272:8198- 8206.Shen,W.F., Rozenfeld,S., Lawrence,H.J. and Largman,C. (1997) The Abd-B-like Hox homeodomain proteins can be subdivided by...
Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect. In particular, suitable compounds may be useful in treating neurodegenerative disea
proteins, isolated using streptavidin beads (Invitrogen), were eluted, subjected to SDS-PAGE, and visualized with Coomassie blue staining. Bands differing in abundance between the CGA-preincubated and control samples were analyzed by LC‒MS/MS using a Q Exactive Mass Spectrometer (Beijing Protein ...
Sialoadhesin (Sn)-expressing monocytes/macrophages have been associated with several diseases like inflammatory and autoimmune disorders as well as viral infections, and they also appear to play a role in the initiation of an adaptive immune response. Th
ASPH Hydroxylates proteins containing EGF-like domains, including NOTCH, regulating activity NOTCH1 Key role in CNS development, cell motility and cell fate decisions JAG1 Ligand for NOTCH 1 HES1 Transcriptional target of NOTCH, regulates cell fate via transcriptional repression (key role in maintenanc...
1b). Fig. 1: Development of the PEAC-seq technique. a Schematic representation of the PEAC-seq experimental procedure. The gDNA was extracted and undergone Tn5 tagmentation. The Tn5 was embedded with UMI adapters to eliminate PCR duplications in silicon. After tagmentation, fragments were ...