A major challenge in understanding gene regulation is the unequivocal identification of enhancer elements and uncovering their connections to genes. We present GeneHancer, a novel database of human enhancers and their inferred target genes, in the framework of GeneCards. First, we integrated a total...
Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful. Growing evide...
Lateral inhibition, wherein a single cell signals to its neighbors to prevent them from adopting its own fate, is the best-known setting for cell-cell comm... B.,Castro - 《Development》 被引量: 229发表: 2005年 Transcription factor AP2-Sp and its target genes in malarial sporozoites The...
作者: RF Deighton,NM Markus,B Al-Mubarak,KFS Bell,S Papadia,PJ Meakin,S Chowdhry,JD Hayes,GE Hardingham 展开 摘要: The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of antioxidant genes, and its activation in astrocytes confers noncell-...
Identifying the genes regulated by the floral homeotic genes APETALA3 (AP3) and PISTILLATA (PI) is crucial for understanding the molecular mechanisms that lead to petal and stamen formation. We have used microarray analysis to conduct a broad survey of genes whose expression is affected by AP3 ...
Finally, we generate a resource of reagents against the genes that are highly homologous to human disease genes. We anticipate that this transgenic RNAi system and the relevant resource will further aid the developmental genetic analysis of the functions and regulation ofDrosophilagenes in the future...
Analysis of bHLH and MYB domain proteins: species-specific regulatory differences are caused by divergent evolution of target anthocyanin genes. Summary: The regulatory anthocyanin loci,: an1, an2, an4 and an11 of Petunia hybrida, and r and c1 from Zea mays, control transcription of different...
Genotyping technology, via molecular markers, has been playing a key role in many biological fields including genetic improvement. Genotyping has been widely applied in multi-national seed companies due to their high-throughput, automatic, large-scale and shared genotyping platforms. Genotyping has moved...
We used an electrophoretic mobility shift assay to identify differences in cMGF promoter-binding proteins in nuclear extracts from AMV- and E26-transformed myeloblasts. As shown in Figure 1B, an oligonucleotide probe, which spanned the A site regulatory element centered around position −86 of ...
A termination codon is recognized as premature if located upstream of an exon–exon junction (13, 11, 60, 66, 67), with a distance of at least 50 nucleotides generally required (13, 11, 60, 66, 67). Importantly, introns are rare in the 3′UTR of mammalian genes, and when they ...