9. The drug combines with triptolide which can lead to accelerate tumor growth in mice, so the combination should be cautious. 10. with allopurinol, the drug may increase liver toxicity. 11. The drug combines with other cytotoxic drugs, increasing the risk of thromboembolism. View all Chemical...
Moreover, AMPK/mTOR pathway may involve in CSC-3436 switched tamoxifen-induced autophagy to apoptosis. The combination of tamoxifen and CSC-3436 produced stronger tumor growth inhibition compared with CSC-3436 or tamoxifen alone treatments in vivo. Conclusion: These data indicated that CSC-3436 ...
The [cis-20]2+ complex showed a growth inhibition, on these two cell lines with IC50 values in the range of 1.25–11 µM. Thus, the [cis-20]2+ isomer, which had a moderate RBA value, showed a antiestrogenic effect towards the MCF7 breast cancer cells, IC50 of 1.25 µM, and ...
SCOPE/IUPAC project on environmental implications of endocrine active substances: Molecular mechanisms of cross- talk between growth factors and nuclear receptor signaling. Pure Appl Chem 75, 1743–1756 (2003). 43. Barratt, H. E. et al. Tamoxifen promotes differentiation of oligodendrocyte progenitors...
Angiogenesis, a major attribute of tumorigenesis, pro- vides a tumor with oxygen and nutrients [4,5]. Several different growth factors and cytokines drive angiogenesis such as VEGF, a predominant pro-angiogenic factor in human cancer [6,7]. Conventionally, stimulated VEGF bind to VEGF receptor ...
Enhancing central nervous system (CNS) myelin regeneration is recognized as an important strategy to ameliorate the devastating consequences of demyelinating diseases such as multiple sclerosis. Previous findings have indicated that myelin proteins, whic
dysfunction or suppression of ER-α has been found to involve in tumor aggressiveness, metastasis and possibly hormone resistance.13,14In the transgenic mouse model, ER-α overexpression in mammary epithelial cells is associated with the precursor lesions15and tumor growth with no aggressive phenotypes...
The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches and/or drugs repurposed to be used as monotherapies or in combination with clinically relevant antibiotics, has become urgent. A therapeutic alternative for infections by multidrug-...
Studies in vitro, as well as in a murine tumor growth inhibition (TGI) model, have demonstrated that the effect of endoxifen ER antagonism is J. Pers. Med. 2017, 7, 20 12 of 20 concentration-dependent [61,110]. Based on pharmacokinetic-pharmacodynamic modeling, optimal TGI was predicted ...
2.10. In Vitro Proliferation Assay Cell growth was first arrested by culturing HepG2 and HepaRG cells in a low-glucose medium for 24 h. The following day, cells were treated with AMI or TMX, alone or with MSC secretome. One set of plates was used to analyze the expression of genes enc...