胆汁酸受体TGR5(Takeda G protein-coupled receptor 5)在血糖稳态、能量消耗和肝脏保护等方面起重要作用,是一个极具潜力的治疗代谢综合征及炎症性疾病的药物靶点。然而,多种已报道的TGR5激动剂在人和小鼠体内存在较大的活性差异,利用现有的啮齿类动物模型开展化合物药效学和毒理学研究会产生偏差。近日,中国科学院上海...
JMC | 上海药物所通过人源化TGR5小鼠研究白桦脂酸衍生物的降糖活性 胆汁酸受体TGR5(Takeda G protein-coupled receptor 5)在血糖稳态、能量消耗和肝脏保护等方面起重要作用,是一个极具潜力的治疗代谢综合征及炎症性疾病的药物靶点。然而,多种已报道的TGR5激动剂在人和小鼠体内存在较大的活性差异,利用现有的啮齿类动物...
Takeda G Protein–Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum Author links open overlay panelHao Wang a 1, Yuan-Zhi Tan a 1, Rong-Hao Mu a, Su-Su Tang a, Xiao Liu a, Shu-Yu...
Takeda G protein-coupled receptor 5(TGR5) is a newly discovered member of G protein-coupled receptor super-family in recent years. It plays an important role of signal molecules in multiple systems of the whole body,and expresses in multiple organs and tissues. Recently,studies have shown that...
Takeda G protein-coupled receptor 5(TGR5)Serotonin(5-HT)High fat,high fructose,and high sucrose(HFS)Background and aims:Diet-induced obesity and metabolic syndrome can trigger the progression of fatty liver disease to non-alcoholic steatohepatitis and fibrosis,which is a major public health concern...
Bile acids play a critical role in the regulation of glucose, lipid and energy metabolisms by activating the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (aka takeda G protein couple receptor 5, TGR5) signaling. Paradoxical roles of...
Farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR-5) are the two most common cholic acid receptors (17,18). FXR and TGR-5 serve an important role in the enterohepatic circulation of cholic acid. FXR, a member of the ligand-activated nuclear receptor superfamily, is...
Bile acids are known to regulate lipid, glucose, and energy homeostasis through activation of FXR2 and TGR5 (Takeda G-protein receptor 5 (also known as Gpbar-1 for G-protein-coupled bile acid receptor-1)) (1, 2). Bile acid synthesis in the liver generates two primary bile acids, cholic...
blood cultures using BACT/ALERT®3D instrument were positive forR. pickettii.According toantibiotic susceptibility test reports,Ciprofloxacin (5 μg)was prescribed. Fortunately, after starting antibiotic treatment, blood culture results reported no growth after 5 days. Indeed, the patient was infected ...
G protein-coupled receptor proteins present on the cell surface of each functional cells and organs in the body, and play important physiological roles as the targets of molecules that regulate the functions of the cells and organs, e.g., hormones, neurotransmitters, physiologically active substances...