胆汁酸受体TGR5(Takeda G protein-coupled receptor 5)在血糖稳态、能量消耗和肝脏保护等方面起重要作用,是一个极具潜力的治疗代谢综合征及炎症性疾病的药物靶点。然而,多种已报道的TGR5激动剂在人和小鼠体内存在较大的活性差异,利用现有的啮齿类动物模型开展化合物药效学和毒理学研究会产生偏差。近日,中国科学院上海...
TGR5 Takeda G protein-coupled receptor 5 Keywords Deoxycholic acid GLP-1 mTORC1 RYGB TGR5 1. Introduction The increase in incidence and prevalence of type 2 diabetes is strongly associated with the obesity epidemic [1]. Roux-en-Y gastric bypass (RYGB) is the most effective approach for weight...
TC-G 1005TC G 1005,G protein-coupled Bile Acid Receptor 1,levels,coupled,glucose,TCG 1005,Takeda,inh产品询价/message 留言框 感兴趣的产品: * 您的单位: * 您的姓名: * 联系电话: * 详细地址: 常用邮箱: 您的任何要求、意见或建议: * 验证码: *...
Bile acids are known to regulate lipid, glucose, and energy homeostasis through activation of FXR2 and TGR5 (Takeda G-protein receptor 5 (also known as Gpbar-1 for G-protein-coupled bile acid receptor-1)) (1, 2). Bile acid synthesis in the liver generates two primary bile acids, cholic...
a G-protein-coupled receptor (GPCR) that appears in insulin-secreting cells in the pancreas. It is hoped that TAK-875 will provide the benefit of reducing blood sugar levels, while reducing the risk of hypoglycemia. Hypoglycaemia (low blood sugar) is a serious and sometime life-threatening si...
TAK-041 is a potential first-in-class G Protein-Coupled Receptor 139 (GPR139) agonist. TAK-041 has completed multiple Phase I studies and is a Phase II study-ready compound with the potential to be developed for the treatment of anhedonia in depression. Anhedonia is a psychological condition...
胆汁酸受体TGR5(Takeda G protein-coupled receptor 5)在血糖稳态、能量消耗和肝脏保护等方面起重要作用,是一个极具潜力的治疗代谢综合征及炎症性疾病的药物靶点。然而,多种已报道的TGR5激动剂在人和小鼠体内存在较大的活性差异,利用现有的啮齿类动物模型开展化合物药效学和毒理学研究会产生偏差。近日,中国科学院上海药...
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods ...
The cannabinoid receptor type 1 (CB1) is a 7-transmembrane cell membrane receptor in the G protein-coupled receptor superfamily expressed primarily in the brain, as well as peripherally in the lungs, liver, kidney, and adipose tissue. CB1 is activated by cannabinoids generated naturally inside the...
The Ca receptor is composed of a large terminal extracellular region spanning 600 amino acids at the N-terminal, having seven transmembrane spanning domains like other G protein coupled receptors, and an intracellular region consisting of 200 or less amino acids at the carboxyl C-terminal. It is...