In this study, we determined the role of PP2Cbeta-1, a major isoform of mammalian PP2C, in the TAK1 signaling pathway, a stress-activated protein kinase cascade that is activated by interleukin-1, transforming growth factor-beta, or stress. Ectopic expression of PP2Cbeta-1 inhibited the TAK...
关键词 维生素D 甲状腺功能减退 肾损伤 上皮细胞间充质转化 肿瘤坏死因子受体相关因子6/转化生长因子-β活化激酶1通路 Vitamin D Hypothyroidism Renal injury Epithelial mesenchymal transition Tumor necrosis factor receptor-associated factor 6/transforming growth factorβactivated kinase 1 signaling pathway 分类号...
1. Ciccolella M, Andreone S, Mancini J, et al. Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models.Cells.2021;10(4). 2. Chen Q, Sun L, Chen ZJ...
Background:TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF...
TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and ...
promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the...
Our data demonstrate that POPX2 is a negative regulator of TAK1 signaling pathway and modulates apoptosis through the regulation of TAK1 activity. As inhibition of TAK1 has been proposed to reduce chemoresistance and increase sensitivity to chemotherapy in certain types of cancer, modulation of POP...
Fig. 5: GCN5 regulates TAK1-JNK/p38 signaling pathway in hypertrophic hearts and cardiomyocytes. A Western blots showing the activity of TAK1-JNK/p38 signaling pathway components in NRCMs infected with AdNull or AdGCN5 for 24 h, followed by treatment with PBS or PE (∗∗P < ...
Dysregulation of TAK1 signaling pathway in mice leads to tissue abnormalities resembling human disease pathogenesis. Open Questions What are the mechanisms by which TAK1 activity is regulated in response to the rich diversity of environmental and endogenous stimuli in vivo? What is the ...
Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast formation. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key downstream effector of the Hippo signaling pathway; it was suggeste...