(2006). Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J. Biol. Chem. 281, 28802-28810.HuangFu W C,Omori E,Akira S,et al.Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB...
TGF-β Signaling via TAK1 Pathway: Role in Kidney Fibrosis In progressive kidney diseases, fibrosis represents the common pathway to end-stage kidney failure. Transforming growth factor-β1 (TGF-β1) is a pleiotrop... ME Choi,Y Ding,SI Kim - 《Seminars in Nephrology》 被引量: 0发表: ...
通路(Pathway) Apoptosis CAS号(CAS NO.) 1111556-37-6 分子式(Formula) C18H18N4O2 分子量(Molecular Weight) 322.36 纯度(Purity) ≥98% 结构式(Structure) 运输和保存方法 粉末-25~-15℃保存,有效期3年;溶于溶剂,-85~-65℃保存,有效期2年
IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK...
(IKK)-NF-κB pathway, which has a number of target genes, many of which block apoptosis, promote cell proliferation and stimulate inflammatory responses.1,2,3Loss of TAK1 sensitizes cells to death through many of the myriad pathways known to activate TAK1, including TNFα. However, ...
Paclitaxel (PTX) has previously been used to treat tumours of various tissue origins, such as lung, breast, ovarian, prostate cancer, and leukemia. PTX﹊nduced apoptosis is associated with p38 MAPK, ERK, NF│蔅 and JNK/ SAPK pathway. TAK1 and TAB1 play an important role in cell ...
2. Chen Q, Sun L, Chen ZJ. Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.Nature immunology.2016;17(10):1142-1149. 3. Barber GN. STING: infection, inflammation and cancer.Nature reviews....
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK. ...
关键词 维生素D 甲状腺功能减退 肾损伤 上皮细胞间充质转化 肿瘤坏死因子受体相关因子6/转化生长因子-β活化激酶1通路 Vitamin D Hypothyroidism Renal injury Epithelial mesenchymal transition Tumor necrosis factor receptor-associated factor 6/transforming growth factorβactivated kinase 1 signaling pathway 分类号...
Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast formation. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key downstream effector of the Hippo signaling pathway; it was suggeste...