(1)TNF信号通路 (2)NF-kappa B信号通路 3、TAK1的磷酸化与泛素化:是TAK1依赖的信号转导过程中的重要调节机制 TAK1重要性 1、TAK1与皮肤、角化细胞:TAK1缺失会引起角化细胞死亡和皮肤炎症 2、TAK1与胚胎致死:TAK1缺陷会导致小鼠胚胎发育异常或死亡 3、TAK1与免疫反应:TAK1缺失会导致LPS或DNA刺激下的B细胞...
Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.应用类型 WB免疫原 Purified recombinant human TAK1 protein fragments expressed in E.coli....
TAK1 also phosphorylates I kappa B kinase β (IKKβ) that leads to the activation of nuclear factor-kappa B (NF-κB) transcription factor18,20. TAK1 has also been found to regulate canonical TGF-β signaling in some cell types. For example, TAK1 is required for the BMP receptor-...
NF-κB is activated and promotes cell death in focal cerebral ischemia. Nat Med 1999; 5: 554–559. Article CAS Google Scholar Inta I, Paxian S, Maegele I, Zhang W, Pizzi M, Spano P et al. Bim and Noxa are candidates to mediate the deleterious effect of the NF-{kappa}B subunit...
关键词: JNK, NF-kappa B, TAB1, TAB2, TAK1, TGF-beta DOI: 10.1101/gad.1360605 被引量: 1061 年份: 2005 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 BMJ 万方 doi.org 万方医学 掌桥科研 查看更多 相似文献 参考文献 引证文献...
Transforming growth factor β activated kinase-1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase family, has emerged as a key regulator of signal transduction cascades leading to the activation of the transcription factors nuclear factor-kappa B (NF-κB) and activator protei...
Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T (2002) TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-[kappa]B signaling pathways. Biochem Biophys Res Commun 297(5):1277–1281 Article PubMed ...
MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-κB Pathway In Vitro Huang, Feng-Ting,Zhuang,etc.MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-kappa B Pathway In Vitro[J]... ...
展开 关键词: Animals Mice Cells, Cultured MAP Kinase Kinase Kinases MAP Kinase Kinase 3 MAP Kinase Kinase 6 p38 Mitogen-Activated Protein Kinases NF-kappa B Osteogenesis Signal Transduction DOI: 10.1038/sj.cdd.4401882 被引量: 183 年份: 2006 收藏...
展开 关键词: Humans B-Lymphocytes Immunoglobulin G Oligodeoxyribonucleotides MAP Kinase Kinase Kinases Mitogen-Activated Protein Kinases NF-kappa B Receptors, Antigen, B-Cell Signal Transduction Lymphocyte Activation DOI: 10.1371/journal.pone.0096381 被引量: 11 年份...