(3 patients hadBehçet's disease, 1 hadmicroscopic polyangiitis, 1 hadpars planitis, and 1 had idiopathic retinal vasculitis) in patients who did not respond to CsA either because of lack of therapeutic effect or unacceptableadverse effects. The posterior uveitis remained controlled in all 6 ...
Tell your doctor if you have any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Tacrolimus Interactions Tell your doctor about all the medicines you take, including ...
This drug passes intobreastmilk and the effect on a nursinginfantis unknown. Consult your doctor beforebreastfeeding. Interactions See also How to Use section. Drug interactionsmay change how yourmedicationswork or increase your risk for serious side effects. This document does not contain all possib...
Hypertension is a common adverse effect of tacrolimus therapy. May require antihypertensive therapy. Monitor relevant drug-drug interactions. Anaphylactic reactions have occurred with injectables containing castor oil derivatives, including tacrolimus injection. Observe patients receiving tacrolimus injection for ...
Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Prograf should be used only when prescribed. This drug passes into breast milk and the effect on a nursing infant is unknown. Consult your doctor before breastfeeding. ...
The effect of hepatic insufficiency on the pharmacokinetics of topically administered tacrolimus has not been evaluated but dose-adjustment is not expected to be needed. Clinical Studies Three randomized, double-blind, vehicle-controlled, multi-center, phase 3 studies were conducted to evaluate PROTOPIC...
It is extensively metabolized in the liver and excreted in the urine.As with cyclosporine, nephrotoxicity is its principal side effect. View all 8.14 Manufacturing Process The novel 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1- methylvinyl]-23,25-dimethoxy-13,19,21,27-...
Table 15: Effects of Other Drugs/Substances on Tacrolimus1 * High dose or double strength grapefruit juice is a strong CYP3A inhibitor; low dose or single strength grapefruit juice is a moderate CYP3A inhibitor. † Strong CYP3A inhibitor/inducer, based on reported effect on exposures to...
We explored the effect of combination of Tacrolimus (TAC) and Sirolimus (SRL) on the immune system in renal transplant recipients. 10 stable renal transplant recipients were selected to participate in a pharmacokinetic study with a combination of TAC and SRL. Blood was drawn on day zero and 14...
fruity smell on your breath confusion nausea, vomiting, or stomach pain kidney problems.Kidney problems are a serious and common side effect of PROGRAF. Your healthcare provider may do blood tests to check your kidney function. nervous system problems.Nervous system problems are a serious and comm...