IS TACROLIMUS A BETTER IMMUNOSUPPRESSANT IN AFRICAN AMERICANS THAN NEORAL-CYCLOSPORINE IN HEART TRANSPLANTATION? FIRST YEAR RESULTS OF A RANDOMIZED CLINICAL TRIALAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00007890-200004271-00697Mandeep R. Mehra...
FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species. Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis. Regulatory elements, present in gene clusters...
tacrolimusBackground: Cyclosporin A is used extensively to prevent the rejection of allogenic renal transplants. However, it is associated with a variety of undesirable side effects including gingival overgrowth. Tacrolimus (FK506), has been marketed as an effective alternative immunosuppressant to ...
Adult heart transplantation under tacrolimus (FK506) immunosuppression: histopathologic observations and comparison to a cyclosporine-based regimen with ly... Background: Tacrolimus (FK506) is an effective immunosuppressant for human heart transplantation, but information about its effects on cardiac allograf...
A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients BACKGROUND: Tacrolimus (Tac) is a potent immunosuppressant with considerable toxicity. Tac pharmacokinetics varies between individuals and thus complicates... E Laure,B Rachida,DA...
Synopsis Tacrolimus (FK 506) is a macrolide immunosuppressant which possesses similar but more potent immunosuppressant properties compared with cyclosporin, inhibiting cell-mediated and humoral immune responses. Like cyclosporin, tacro... DH Peters,A Fitton,GL Plosker,... - 《Drugs》 被引量: 300发...
The i.v. calcineurin inhibitors (tacrolimus and cyclosporine) are mainly used during hospital stay. Steroid such as methylprednisolone is almost universally used. Most recipients are also discharged with the oral tacrolimus as a primary immunosuppressant, with steroids which are gradually tapered and ...
Tacrolimus may substitute for cyclosporine because it has a more potent immunosuppressant capacity and lower risk of kidney toxicity Antithymocyte globulin is given before HCT in unrelated-donor transplants Once a patient has been diagnosed with acute graft versus host disease (GVHD), first-line treat...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook CNI (redirected fromCalcineurin Inhibitor) Category filter: AcronymDefinition CNICentro Nacional de Inteligencia(Madrid, Spain) CNICentre National de l'Informatique(French: National Informatics Center; Tunisia) ...
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