Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells. Proc. Natl. Acad. Sci. USA 98:11644- 11649.Mengozzi M,Malipatlolla M,De-Rosa SC,Herzenberg LA,Herzenberg LA,Roederer M. Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 ...
The mechanisms regulating the differentiation of naive CD4 T cells into Th1/Th2 subsets have been intensively investigated in the mouse. This report summarizes the current knowledge regarding naive human CD4 T cell maturation in vitro. The Thl/Th2 dichotomy is less absolute in human than in mouse...
Naive CD4(+) T Cells Carrying a TLR2 Agonist Overcome TGF-beta-Mediated Tumor Immune Evasion 来自 万方 喜欢 0 阅读量: 17 作者: Ibrahim,Mohsen,Scozzi,Davide,Toth,A Kelsey,Ponti,Donatella,Kreisel,Daniel 展开 摘要: TLR agonists are effective at treating superficial cancerous lesions, but...
Poor T cell immunity is one of the many defects seen in elderly humans and aged (Ad) mice. We report that naive CD4 T cells from aged mice (ANCD4 cells) showed greater apoptosis upon primary activation than those from young (Yg) mice, with loss of mitochondrial membrane potential, poor ...
CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice Trimolecular interactions between the T cell antigen receptor and MHC/peptide complexes, together with costimulatory molecules and cytokines, control the initial activation of naive T cells and determine whether the hel...
Na?ve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation. S, Ametani A et al (2011) Naive CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation. Immu... M Hashiguchi,S...
Memory or antigen-experienced CD4 T cells differ from naive CD4 T cells both phenotypically by cell surface marker expression, and functionally by their dissimilar pattern of cytokine secretion and activation requirements through their T cell receptor (TCR). We show here that activation of memory CD4...
SingleNaiveCD4+TCellsfromaDiverseRepertoireProduceDifferentEffectorCellTypesduringInfectionNoahJ.Tubo,1AntonioJ.Paga´n,1JustinJ.Taylor,1RyanW.Ne..
Therapy was independent of vaccination, exogenous cytokine support, CD8(+), B, natural killer (NK), and NKT cells. Proper activation of CD4(+) T cells in vivo was important for tumor clearance, as naive tumor-specific CD4(+) T cells could not completely treat tumor in lymphopenic common ...
We have previously shown that conventional as well as germ-free CD4 1 T cells depleted of CD25 1 cells from the gut-associated lymphoid tissue and the periphery proliferate specifically in response to enterobacterial antigen exposure whereas unfractionated CD4 1 T cells are not reactive under these...