Editing naive CD4+ T cellsAs last we can edit the immune system's sleeping giants, as CRISPR tools advance into the world of naive CD4+T cells.doi:10.1038/s41592-021-01332-yAndrea Olga PapadopoulosZaza Mtine NdhlovuNature Methods
cultures because the short-term T cell expansion protocol uses minimal stimulants with low dose IL-2, synthetic peptides and no additional cytokines, co-stimulatory signals or antigen-presenting cells, thus preferentially favoring the proliferation of antigen-experienced cells over any naive cells. Rec...