It is based on Xenopus laevis tadpoles, a particularly sensitive model system for studying the physiology and disruption of thyroid hormone signaling: amphibian metamorphosis is a spectacular (thus easy to monitor) life cycle transition governed by thyroid hormones. With a long-te...
但越来越多的研究证实,LT3S与患者病情及预后相关,病情越重,血清T3水平越低,若同时合并T4水平下降,则提示患者病情加重,T3降低的程度与急性生理与慢性健康评分Ⅱ(acute physiology and chronic healthevaluationⅡ,APACHEⅡ)、疾病严重程度呈正相关,临床可通过监测血清T3、T4水平联合AP...
While overexpression of GPAT3 and GPAT4 in either insect or mammalian cells results in a comparable increase of GPAT activity, shRNA-mediated knockdown of GPAT3, but not GPAT4, in 3T3-L1 adipocytes led to a significant decrease in GPAT activity, a profound inhibition of lipid accumulation, ...
- 《American Journal of Physiology》 被引量: 477发表: 1980年 Comparison of the effects of propylthiouracil, amiodarone, diphenylhydantoin, phenobarbital, and 3-methylcholanthrene on hepatic and renal T4 metabolism an... PTU and PB, by decreasing both serum tetraiodothyronine (T4) and ...
M. (2004), Effect of Cold Exposure on Serum DBH and Interscapular Brown Adipose Tissue MAO Activity in Hypothyroid T3- and T4-Treated Rats. Annals of the New York Academy of Sciences, 1018: 214–218. doi: 10.1196/annals.1296.025 Author Information 1 Institute of Physiology and Biochemistry,...
doi:10.1016/j.jmb.2014.10.026Ommolbanin Amoo-RajabiAli MoghimiHomayoon KhazaliPhysiology and PharmacologyAmoo-Raiabi O, Moghimi A, Khazali H, Effect of ICV injection of ghrelin and leptin on T3 and T4 plasma levels in Rat. Physiol Pharmacol 16 (2012) 70-78....
Larsen PR. Triiodothyronine: Review of Recent Studies of Its Physiology and Pathophysiology in Man. Metabolism 1972; 21: 1073-1092. 2. Klee GG. Clinical usage reco endations and analytic performance goals for total and free triiodothyronine 第 5 页 共 6 页 3. measurements. Clinical Chemistry ...
1. 1. Chronic exposure of female Syrian hamsters ( Mesocricetus auratus) for 9 weeks to a short photoperiod (10L:14D) depressed the pituitary-thyroid axis ... MK Vaughan,MC Powanda,BA Richardson,... - Comparative Biochemistry and Physiology -- Part A: Physiology 被引量: 78发表: 1982年 ...
Thus, better understanding the molecular mechanisms underlying the BAT development and physiology is of both broad biological interest and high clinical relevance. About 50 g of active BAT may account for a 20% daily increase in energy expenditure in human, suggesting that BAT serves as a ...
若患者存在严重的消耗性疾病(如恶性肿瘤、严重感染、重度营养不良、肝硬化、肾功能不全、严重创伤及大手术等),血清 TT3、FT3 降低,血清 rT3 升高,血清 TT、FT4 及 TSH 正常或略低,同时排除原发性或继发性甲减后,即可诊断「低 T3 综合征」或「低 ...