然而最近,我们在日本京都大学(Kyoto University)的实验室、美国华盛顿大学(University of Washington)亚历山大·鲁登斯基(AlexanderRudensky)的研究小组以及位于华盛顿州伯瑟尔市CellTech公司研发部的弗雷德·拉姆斯德尔(Fred Ramsdell)研究小组所作的研究,分别发现了有关T-reg细胞如何发育、如何发挥功能的新线索。在T-reg细胞...
We found that the phosphatase PTEN links T-reg cell stability to repression of type 1 helper T cell (T(H)1 cell) and follicular helper T cell (T-FH cell) responses. Depletion of PTEN in T-reg cells resulted in excessive T-FH cell and germinal center responses and spontaneous ...
The researchers have demonstrated an in vivo infection model using ovalbumin-specific T cell response linked to the reduction of interferon production. The findings propose that suppression of regulatory T cells can explain how autoimmune and foreign-antigen-specific responses....
摘要: How regulatory T cells dampen T cell responses in vivo remains unclear. Direct visualization of regulatory T cell activity in an autoimmune setting provides exciting new insights into regulatory T cell-mediated suppression.关键词:DENDRITIC CELLS TOLERANCE DYNAMICS CD4(+)CD25 HOMEOSTASIS INDUCTION ...
【关键词】乳腺癌;淋巴细胞绝对数;调节性T细胞;转移;预后中图分类号:R737.9文献标识码:B文章编号:1671-8194(2012)31-0001-03 RelationshipbetweenthePeripheralBloodAbsoluteLymphocyteCountandTumorInfiltratingT-regCellCountandtheClinicopathologicalCharacteristicsofBreastCancerPatientsUndergoingChemotherapyafterOperation CHENJie...
Foxp3 operates as a late-acting differentiation factor controlling T(reg) cell homeostasis and function, whereas the early T(reg)-cell-lineage commitment is regulated by the Akt kinase and the forkhead box O (Foxo) family of transcription factors. However, whether Foxo proteins act beyond the ...
The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, including immune signals and metabolic cues, to direct T cell fate decisions1. Activation of mTOR, comprised of mTORC1 and mTORC2 complexes, delivers an obligatory signal for proper activation and differentiation...
CD4+CD25+调控T细胞(regulatoryTcell,TReg)具有免疫无能性和免疫抑制性两大功能特征,是机体维持自身耐受的重要组成部分,其对免疫反应具有抑制效应.在免疫病理,移植物免疫耐受以及阻止自身免疫反应和维持机体免疫平衡诸方面都有一定作用.Foxp3在调控TReg细胞的生长发育中起十分重要的作用.近年来的一些研究表明,供体TReg细胞...
限制肿瘤微环境(TME)中的代谢竞争可能会提高免疫疗法的有效性。由于其在活化的T细胞的葡萄糖代谢中的关键作用,已提出CD28信号传导作为T细胞代谢生物传感器。 Conversely, CTLA-4 engagement has been shown to down-regulate T-cell gl...
In conclusion, we found that linc-POU3F3 could promote the distribution of Tregs in peripheral blood T cell which caused an enhanced cell proliferation of gastric cancer cells by recruiting TGF-beta as well as activating TGF-beta signal pathway. This finding may provide a theoretical basis for ...