(PD-L1), has enabled T cell-mediated tumor regression for a range of malignancies including melanoma [9, 10], ovarian [11], lung [12], bladder [13], renal-cell carcinoma [14], Hodgkin’s lymphoma [15], as well as colorectal, gastrointestinal and endometrial cancers having DNA mismatch ...
For angioimmunoblastic T cell lymphoma (AITL), a rare cancer, no specific treatments are available and survival outcome is poor. We previously developed a murine model for AITL that mimics closely human disease and allows to evaluate new treatments. As i
There was no difference in the mortality rate among admissions with non-Hodgkin's Lymphoma, Multiple Myeloma, and Leukemia that utilized CAR-T therapy. Conclusions: In this largest study to date, we illuminate the incidence and outcomes of CAR-T cell therapy admissions wit...
CD226, also known as DNAX accessory molecule 1 (DNAM-1), is an immunoglobulin-like transmembrane glycoprotein consisting of two immunoglobulin V-like domains, a type-I transmembrane domain, and an intracellular domain (ICD) with an immunoglobulin tail tyrosine (ITT). CD226 is broadly expressed at...
SS1 CAR T-cells with varying endodomains exhibit differing immunophenotypes.ASchematic of 4-1BBζ, CD28ζ and Mutζ SS1 CAR constructs expressed via Moloney murine leukaemia retroviral vectors. SP: Signal peptide; scFv: Single chain variable fragment; TM: Transmembrane; ICD: Intracellular domain....
(EGFR) CAR-T cells with glioblastoma cells transfected with sgRNA for CRISPR screening demonstrated that the IFN-γ-R signaling pathway confers greater resistance to CAR-T cell killing in glioblastoma and other solid tumors, but not in leukemia and lymphoma, indicating distinct effects between solid...
Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma (HCC) are urgently needed. The common cytokine receptor γ chain (γc) family cytokines such as IL-2, IL-7, IL-15 and IL-21 play fundamental roles in T cell de
Keywords: T follicular helper cells; TFH lymphoma; angioimmunoblastic T-cell lymphoma; follicular T-cell lymphoma; peripheral T-cell lymphoma of T-follicular helper immunophenotype; peripheral T-cell lymphoma Citation: Ganapathi, K.A.; Karner, K.H.; Menon, M.P. Peripheral T-Cell Lymphomas of...
Keywords: T-cell lymphoma; anthracycline-based chemotherapy; DNA damage response; ATM inhibition; AZD0156; drug combination 1. Introduction Nodal T-cell lymphomas (TCL) are a rare and aggressive subgroup of lymphoid ma- lignancies, accounting for 10–15% of non-Hodgkin lymphomas (NHL). ...
Gemcitabine, L-asparaginase, Isophosphomide, Dexamethasone and Etoposide (GLIDE) In Patients with Newly Diagnosed Stage III/IV and Recurrent or Refractory Aggressive NK/T Cell Lymphoma,West China Hospital,Observational,Phase 2