Enteropathy-associated T-cell lymphoma (EATL) is associated with celiac disease. With the rising prevalence of celiac disease, we hypothesized that the prevalence of EATL is also increasing. We used the Surveillance, Epidemiology, and End Results database, which is a population-based US cancer ...
4. Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy 译：动态监测循环肿瘤DNA 揭示接受 CAR T 细胞治疗的复发或难治性大 B 细胞淋巴瘤患者的结果和基因组变化 作者列表:Zou H;L...
Immunotherapies, specifically immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1(PD-L1), provided a significant advance in cancer treatment [1]. CAR-T cell therapy is a novel form of immunotherapy that employs genetic engineer...
Our data suggest that such inhibitors may be efficacious and sufficient in treatment of lymphoma and leukemia by direct inhibition of DNA synthesis. In conclusion, we propose a model where c-Myc-dependent Txnip downregulation by T-cell activation is critical for release of active Trx1 that in ...
However, Tph cells display features distinct from those of Tfh cells, such as the expression of chemokine receptors associated with Tph cell localization within inflamed tissues and a low Bcl-6/Blimp1 ratio. Unlike that of Tfh cells, current evidence shows that the target of Tph cells is ...
Before the FDA approval of two chimeric antigen receptor T-cell therapies, children and young adults with B-cell acute lymphoblastic leukemia and adults with relapsed or refractory diffuse large B-cell lymphoma were considered incurable.Chimeric antigen
LtxA concentration curve to which the intensity of the OMV and cell spots could be compared. Using this method, we calculated that LtxA comprised approximately 40% (by mass) of the protein composition of the JP2 OMVs but only 2% of the protein composition of the JP2 cells. Toxins 2018, ...
Although DAp was the most potent cytotoxic agent against all cancer cell lines, we decided to work on IAp because it was the most prominent alkaloid (84.74%) in the active fraction and showed comparable activity to DAp. IAp exhibited the most potent activity against T-47D cell line suggesting...
Irinotecan plus cisplatin and dexamethasone (ICD) combination chemotherapy for patients with diffuse large B-cell lymphoma previously treated with Rituxima... PURPOSE: The therapeutic strategy for relapsed or refractory patients with diffuse large B-cell lymphoma (DLBL) remains challenging yet. Salvage ...
together with an intronic variant in a downstream gene,SMAD3, points to defective TGFβR1 signaling as one of the biological perturbations increasing asthma risk. Our results increase the number of asthma variants and implicate genes with known role in T cell regulation, inflammation and airway ...