在近期发表在Cell Metabolism杂志上的一篇题为“T-bet+B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity”的文章中,研究人员揭示了肥胖期间T-bet+B细胞对代谢紊乱和糖尿病的作用。脂肪组织T-bet+B细胞在体重指数(BMI)增加的人群和体重增加的小鼠中积累。在肥胖期间,受到TLR7或...
近日,来自美国德克萨斯大学医学中心(UT Health)的Elizabeth A. Leadbetter团队在Cell Metabolism上在线发表题为T-bet+B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity的文章,描述了T-bet+B细胞在肥胖加剧代谢...
与来自相同供体的 T-bet - B 细胞相比,从超重或肥胖的受试者中分离的T-bet + B 细胞表现出不同的表型,人类和小鼠之间具有许多共同特征。引人注目的是,与来自匹配受试者的 T-bet - B 细胞相比,肥胖人群或 HFD 小鼠中的T-...
The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation ...
近日,来自美国德克萨斯大学医学中心(UT Health)的Elizabeth A. Leadbetter团队在Cell Metabolism上在线发表题为T-bet+B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity的文章,描述了T-bet+B细胞在肥胖加剧代谢紊乱和糖尿病症状中的作用,阐明了T-bet+B细胞在小鼠和人类的进行性肥胖...
10. Szabo, S.J., Sullivan, B.M., Stemmann, C., Satoskar, A.R., Sleckman, B.P., and Glimcher, L.H. (2002). Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295, 338–342.11. Davis MM, Brodin P. Rebooting Human...
10. Szabo, S.J., Sullivan, B.M., Stemmann, C., Satoskar, A.R., Sleckman, B.P., and Glimcher, L.H. (2002). Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295, 338–342. 11. Davis MM, Brodin P. Rebooting Huma...
耗竭的T细胞失去强大的效应功能,表达多种抑制受体,并通过改变的转录程序来定义。T细胞耗竭通常与对持续感染和肿瘤的控制效率低下有关,但激活耗尽的T细胞可以重新激活免疫力(revitalization of exhausted T cells can reinvigorate immunity)。 1、T细胞衰竭的渐进发展...
耗竭的T细胞失去强大的效应功能,表达多种抑制受体,并通过改变的转录程序来定义。T细胞耗竭通常与对持续感染和肿瘤的控制效率低下有关,但激活耗尽的T细胞可以重新激活免疫力(revitalization of exhausted T cells can reinvigorate immunity)。 1、T细胞衰竭的渐进发展...
2024年4月28日,休斯顿卫理会医院研究所(Houston Methodist Research Institute)的科学家们在Advanced Science发表了题为T‐bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells的研究论文【5】。该研究发现...