随后的研究发现 T-bet 并非仅仅在 T 细胞中表达,在树突状细胞(DC)、自然杀伤细胞(NK), 自然杀伤性 T细胞(NKT)和先天性淋巴样细胞(ILC)、CD8+ T 细胞、B 细胞 ,调节性 T细胞(Treg)等其他多种免疫细胞中也能检测到 T-bet 的表达,并且在...
最终,如果感染的严重程度或持续时间较高或较长,virus-specific T cells病毒特异性T细胞可能会丢失。 耗竭的T细胞分为T-bet hi PD1mid(耗竭性T细胞前体Precursor exhausted T )和EOMES hi PD1 hi (终末分化耗竭性T细胞Terminal Exhausted T)CD8+耗尽的T细胞亚群,只有T-bet hi PD1 mid亚型可通过阻止PD-1通路来恢...
10. Szabo, S.J., Sullivan, B.M., Stemmann, C., Satoskar, A.R., Sleckman, B.P., and Glimcher, L.H. (2002). Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295, 338–342.11. Davis MM, Brodin P. Rebooting Human...
2025年2月5日,西湖大学医学院董晨团队在Journal of Experimental Medicine上发表了题为“Regulatory T cells converted from T helper 1 cells in tumors suppress cancer immunity via CD39”的研究论文。该研究深入解析了肿瘤内调节性(Treg)细胞的发育路径与功能特性,揭示了T-bet+Treg细胞在肿瘤免疫中的关键作用,发...
CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines. Blood. 2012;120(23):4552-9.Serre K, Cunningham AF, Coughlan RE, Lino AC, Rot A, Hub E, et al. CD8 T cells induce T-bet-dependent migration ...
Ectopic T-bet expression by OT-I CD8+ T cells stimulated by the H2-Kb (SIINFEKL) complex and cultured with 2ng/mL IL-2 induced a coordinated change in gene expression leading to down-regulation of CD127 and SOCS-1 and up-regulation of CD122 and IL-15 receptor , switching the ...
研究人员发现与自身脂肪组织T-bet-B细胞相比,T-bet+B细胞表面CD27表达量略低,但没有统计学意义(辅图2)。因此,来自超重和肥胖患者的T-bet+B细胞表现出活化B细胞的特征,包括CD11c、CD69和Nur77表达的上调(小编注:CD1c/CD1d可以呈递脂质或者糖脂抗原给T细胞,产生T细胞活化的辅助信号,CD27是一种CD4+和CD8+T细胞...
10. Szabo, S.J., Sullivan, B.M., Stemmann, C., Satoskar, A.R., Sleckman, B.P., and Glimcher, L.H. (2002). Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 ...
(2002). Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295, 338–342. 11. Davis MM, Brodin P. Rebooting Human Immunology. Annu Rev Immunol. 2018 Apr 26;36:843-864. doi: 10.1146/annurev-immunol-042617-053206. Epub 2018 ...
关键词:T-bet;Eomes;CD8+T细胞;TSCM;IL-33;ST2作者:李刚指导老师:张学光卢斌峰转录因子T-bet、Eomes和IL-33对CD8+记忆和效应T细胞抗肿瘤的作用机制英文摘要TheroleoftranscriptionfactorT-bet/EomesandIL-33inregulatingtheanti-tumoreffectofCD8+memoryTcellsandeffectorTcellsAbstractAnti-tumorimmuneresponsesaremainly...