在近期发表在Cell Metabolism杂志上的一篇题为“T-bet+B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity”的文章中,研究人员揭示了肥胖期间T-bet+B细胞对代谢紊乱和糖尿病的作用。脂肪组织T-bet+B细胞在体重指数(BMI)增加的人群和体重增加的小鼠中积累。在肥胖期间,受到TLR7或...
近日,来自美国德克萨斯大学医学中心(UT Health)的Elizabeth A. Leadbetter团队在Cell Metabolism上在线发表题为T-bet+B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity的文章,描述了T-bet+B细胞在肥胖加剧代谢...
The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation ...
与来自相同供体的 T-bet - B 细胞相比,从超重或肥胖的受试者中分离的T-bet + B 细胞表现出不同的表型,人类和小鼠之间具有许多共同特征。引人注目的是,与来自匹配受试者的 T-bet - B 细胞相比,肥胖人群或 HFD 小鼠中的T-...
近日,来自美国德克萨斯大学医学中心(UT Health)的Elizabeth A. Leadbetter团队在Cell Metabolism上在线发表题为T-bet+B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity的文章,描述了T-bet+B细胞在肥胖加剧代谢紊乱和糖尿病症状中的作用,阐明了T-bet+B细胞在小鼠和人类的进行性肥胖...
10. Szabo, S.J., Sullivan, B.M., Stemmann, C., Satoskar, A.R., Sleckman, B.P., and Glimcher, L.H. (2002). Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295, 338–342.11. Davis MM, Brodin P. Rebooting Human...
of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells. ...
Ly et al. report that that germinal center (GC) B cells upregulate the transcription factor T-bet during infection. T-bet favors commitment of B cells to the GC dark zone, thereby augmenting immunoglobulin gene mutation rates and antibody affinity maturation. Keywords: malaria, T-bet, B cells...
2025年2月5日,西湖大学医学院董晨团队在Journal of Experimental Medicine上发表了题为“Regulatory T cells converted from T helper 1 cells in tumors suppress cancer immunity via CD39”的研究论文。该研究深入解析了肿瘤内调节性(Treg)细胞的发育路径与功能特性,揭示了T-bet+Treg细胞在肿瘤免疫中的关键作用,发...
10. Szabo, S.J., Sullivan, B.M., Stemmann, C., Satoskar, A.R., Sleckman, B.P., and Glimcher, L.H. (2002). Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.Science295, 338–342. ...