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a, PDHc activity of CD8+T cells treated with DEG for 30 min (acute) or 7 days (chronic), normalized to total protein concentration. Two-tailed, pairedt-test; acute,n = 9; chronic,n = 14.b, Basal ECAR in CD8+T cells as determined by Seahorse analysis after 30-min DEG ...
and are analysed by log-rank test (b–g, j and k) or one-way ANOVA and Tukey’s test (i). Schematics in a,h created using BioRender (https://Biorender.com). Source Data Full size image We next extended this combinatory strategy to CAR-T cell therapy in a s.c. mouse MC38 ...
The results showed an increased level of Tfh cells reactivated from CD4+ Tcm cells compared to those reactivated from CD4+ Tem cells in CD4+/+Bob1fl/fl mice (Fig. 5b). These findings are consistent with those of previous studies indicating that CD4+ Tcm cells were a more efficient source...
(n = 3; mean ± s.e.m., two-tailed, paired Student’st-test).c,d, Real-time analysis of the ECAR (c) and OCR (d) by human CD8+CD45RA−T cells using a Seahorse Extracellular Flux Analyzer. The dotted lines show the time point of addition of the indicated substances....
(TR) Loci in the Adaptive Immune Response: The Tale of the TRG Locus in Mammals Rachele Antonacci 1,* , Serafina Massari 2, Giovanna Linguiti 1, Anna Caputi Jambrenghi 3 , Francesco Giannico 3 , Marie-Paule Lefranc 4 and Salvatrice Ciccarese 1 1 Department of ...
(A) Non-parametric Wilcoxon rank sum test was used to compare gene expression of cells in one cluster versus those in the other two clusters (clusters as defined in Figure 4D) followed by pre-ranked GSEA [based on log2 fold change (FC)] using the C7 immunological collections. Shown are ...
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