They are capable of penetrating into and damaging the DNA of a cell so the cell will produce mutated cells that can replicate out of control. Cellular defenses against oxidants are antioxidant enzymes (such as catalase, superoxide dismutase, and peroxi- dases.) and antioxidant molecules (such ...
In this study, we present a sample-efficient, free-solution method, termed microscale thermophoresis, that is capable of analysing interactions of proteins or small molecules in biological liquids such as blood serum or cell lysate. The technique is based on the thermophoresis of molecules, which ...
As used herein, the term “solvate” refers to an association or complex of one or more solvent molecules and a compound of the disclosure. Examples of solvents that form solvates may include water, isopropanol, ethanol, methanol, dimethylsulfoxide, ethylacetate, acetic acid and ethanolamine. As...
This property offers a way to test the relevance of nodes with respect to the overall network connectivity, which can be measured by the average shortest path - where the shortest path between two nodes is the minimum number of edges connecting them and the average shortest path is the mean ...
In order to compare the results and in the absence of common data regarding GPCRs, the activation in these simulations were performed using 85,000 molecules of GPCRs, i.e. corresponding to the same concentration of receptors for a normal human platelet. Given that HeLa cell protein numbers ...
The molecules were compared with the properties of known drugs: the prediction was based on the generation of a ‘similarity matrix’ of fragments of the studied molecule. A full description of the in silico evaluation of the pharmacokinetic parameters of the synthesized compounds is given in the...
molecules Article Synthesis, Characterization and Biological Activities of Biopolymeric Schiff Bases Prepared with Chitosan and Salicylaldehydes and Their Pd(II) and Pt(II) Complexes Hellen Franciane Gonçalves Barbosa 1 ID , Maha Attjioui 2, Ana Paula Garcia Ferreira 1, Edward Ralph Dockal 3 ID ...
molecules Article Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease Weiam Hussein 1,2, Begüm Nurpelin Sag˘ lık 2,3, Serkan Levent 2,3, Büs¸ra Korkut 4, Sinem Ilgın 4, Yusuf Özkay 2,3,* ID and Zafer Asım Kaplancıklı 2...
For this reason, the correct description and understanding of noncovalent interactions between molecules is essential for being successful in this field of research. In general, strong and highly directional interactions, such as hydrogen bonding and σ-hole bonding [7–17], and less directional ...
Reagents and conditions: (a) CH3CH2OH, 60 °C, 1 h; (b) CH3COOCr, 80 °C,18 h; (c) maturing 48 h. Scheme 5. Synthesis of compound 5. Molecules 2015, 20 17022 2.2. Biological Activity 2.2.1. Study of the Hypoglycemic Activity of Individual Compounds Many anti-diabetic isoflavonoids...