Unity of invention will exist when the polynucleotide molecules, as claimed, share a general inventive concept, i.e., share a technical feature which makes a contribution over the prior art.” (http://www.uspto.gov/web/offices/com/sol/og/2007/week13/patsequ.htm) Electronic submission using...
Free radicals are highly unstable molecules that interact quickly and aggressively with other molecules in our bodies to create abnormal cells (Kim et al., 2003). They are capable of penetrating into and damaging the DNA of a cell so the cell will produce mutated cells that can replicate out...
In this study, we present a sample-efficient, free-solution method, termed microscale thermophoresis, that is capable of analysing interactions of proteins or small molecules in biological liquids such as blood serum or cell lysate. The technique is based on the thermophoresis of molecules, which ...
Also, LMWHA enhances the synthesis of type I and VIII collagen, which are ECM molecules of the endothelial cell angiogenic phenotype. Low and intermediate molecular weight (2 × 104–4.5 × 105) HA oligosaccharides are potent stimulators of inflammatory cyto- kine and adhesion molecules (Noble ...
As used herein, the term “solvate” refers to an association or complex of one or more solvent molecules and a compound of the disclosure. Examples of solvents that form solvates may include water, isopropanol, ethanol, methanol, dimethylsulfoxide, ethylacetate, acetic acid and ethanolamine. As...
Redox status, denoting the equilibrium between reduced and oxidized molecules within the organism, assumes a central role in regulating cellular functions and signaling pathways. It is widely acknowledged that the thiol/glutathione disulfide (GSH) ratio represents a critical determinant of redox status. ...
molecules Article Synthesis, Characterization and Biological Activities of Biopolymeric Schiff Bases Prepared with Chitosan and Salicylaldehydes and Their Pd(II) and Pt(II) Complexes Hellen Franciane Gonçalves Barbosa 1 ID , Maha Attjioui 2, Ana Paula Garcia Ferreira 1, Edward Ralph Dockal 3 ID ...
Even if horizontally acquired PCWDEs are widespread in beetles (McKenna et al., 2019), co-opting symbionts that produce these same molecules may be more common than currently thought particularly when means of vertical transmission and morphological adaptations to accommodate the microbes in the ...
& Yang, C. The microrna-200 family: small molecules with novel roles in cancer development, progression and therapy. Oncotarget 6, 6472–98, doi: 10.18632/oncotarget.3052 (2015). 26. Zhao, S. et al. Microrna-203 regulates growth and metastasis of breast cancer. Cellular Physiology and ...
In order to compare the results and in the absence of common data regarding GPCRs, the activation in these simulations were performed using 85,000 molecules of GPCRs, i.e. corresponding to the same concentration of receptors for a normal human platelet. Given that HeLa cell protein numbers ...