大多数患者的循环LGL数量持续上升,范围在1000-6000/ul之间。根据WHO 2017分类,持续循环LGL大于2000/ul(正常值小于300/ul)超过6个月是诊断的必要条件。 然而,许多患者的克隆性LGL数量较少,通常伴有其他临床或血液学特征,如类风湿性关节炎(RA)或细胞减少症。因此,即使LGL计数...
大多数患者的循环LGL数量持续上升,范围在1000-6000/ul之间。根据WHO 2017分类,持续循环LGL大于2000/ul(正常值小于300/ul)超过6个月是诊断的必要条件。 然而,许多患者的克隆性LGL数量较少,通常伴有其他临床或血液学特征,如类风湿性关节炎(RA)或细胞减少症。因此,即使LGL计数低于2000/ul,只要符合其他所有标准,也可...
T-cell large granular lymphocyte leukemia (LGL) This is an indolent leukemia characterized by >2000 LGL cells/mm3 of blood for 6 months or more. It may be accompanied by cytopenia (most often neutropenia) and is associated with autoimmune diseases. CD3+, CD8+, and positive for cytotoxic...
T-LGL leukemiadoi:10.1038/S41375-019-0471-3Klara KleinAgnieszka Witalisz-SieprackaBarbara MaurerDaniela PrinzGerwin HellerNicoletta LeidenfrostMichaela Prchal-MurphyTobias SuskeRichard MorigglVeronika SexlLeukemia
Adult T cell–like lymphoma/leukemia Angioimmunoblastic lymphoma Angiotropic lymphoma Intestinal T cell lymphoma Anaplastic large cell lymphoma MALT,Mucosa-associatedlymphoid tissue;LGL,large granular lymphocyte;NK,natural killer. Read full chapterView PDFExplore book...
Clonal CD8+/T-cell receptor (TCR)αβ+ T-cell large granular lymphocyte (T-LGL) proliferations constitute the most common subtype of T-LGL leukemia. Although the etiology of T-LGL leukemia is largely unknown, it has been hypothesized that chronic antigen
APL 23 4 Pneumonia, septicemia Apergillus pneumonia NK-LGL,GI overlap syndrome Died fungal pneumonia 648 CML 27 2 Cellulitis None Alive 528 RTX indicates Rituximab; SCT, stem cell transplantation; AML, acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; APL, acute promyelocytic leukemia; ...
Large granular lymphocyte (LGL) leukemia is a well-recognized disease of mature T-CD8(+) or less frequently natural killer cells; in contrast, monoclonal e... Lima M; Almeida J; Dos Anjos Teixeira M; Alguero Md Mdel C; Santos AH; Balanzategui A; Queirós ML; Bárcena P; Izarra A; ...
This is a case with clinical presentation more compatible with T-large granular lymphocytic leukemia (T-LGL) and clinically followed as such, until it manifested clinically aggressively with B symptoms, splenomegaly, lymphadenopathy, and morphologically compatible with HSTL. This case continued to ...
K562 (leukemia) cells were incubated with FL-PLE overnight. Cell integration of FL-PLE was analyzed by flow cytometry (FIG. 7A). There was a clear shift from the control K562 parental with the K562 parental incubated with 5 μM FL-PLE, whereas there was a very slight shift with K562 ...