Allergy | Regulatory T cells | T cellsdoi:10.1038/nri2310
In recent years, Tregs have been emerging as key focus in the sensitization phase of the pathogenesis of allergy. It is recognized that acquired immunity is controlled by Tregs that suppress responses of effector T cells. Tregs can be classified into nTregs [6] including inducible costimulator (...
[28] Bending D, Pesenacker A M, Ursu S, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis...
L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145–173 (1989). CAS PubMed Google Scholar Romagnani, S. Regulation of the development of type 2 T-helper cells in allergy. Curr. Opin. Immunol. 6, 838...
T-cell toleranceto self-antigens is achieved by the deletion of autoreactiveT cellsin thethymusor inactivation of autoreactive T cells in the periphery. However, the molecular mechanisms underlying the initiation and maintenance of T-cell tolerance are still unclear. The differential negative regulati...
Our results demonstrated that the administration of baicalein ameliorated the symptoms of food allergy and attenuated serum IgE and effector T cells. However, Treg-related factors were up-regulated by baicalein. Furthermore, baicalein was shown to enhance intestinal barrier function through the ...
(E) The relationship between the compensated FRET ratio and the apparent energy transfer efficiency (Eapp) obtained by partial and complete photobleaching of acceptor in CD4-CFP-YFP-expressing cells (circles). Solid line represents theoretical function of E and the compensated FRET ratio derived from...
and its pathogenesis remains elusive.There are diverse immune cells involved in the formation of asthma, including T lymphocytes, eosinophils, neutrophils, etc.Due to the continuous renewal of classification and function of T lymphocytes subsets, their role...
In terms of effector function, IFNγ has been shown to have a role in the clearance of various bacterial, parasitic, viral or fungal infections14–16; how‑ ever, there are many examples in which the frequency of IFNγ-producing T cells is not a sufficient immune cor‑ relate of ...
The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of Treg cells results in a fatal autoimmune disease featuring all known types