While the role of immunoglobulin E (IgE)-mediated responses in allergies has been extensively studied, recent research has shed light on the pivotal role of Tcells in orchestrating and modulating immune responses. Investigating Tcell function in food allergy is essential for understanding the ...
[28] Bending D, Pesenacker A M, Ursu S, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis...
The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of Treg cells results in a fatal autoimmune disease featuring all known types
AllergyA.B. Kay, T cells in allergy and anergy, Allergy 54 (Suppl. 56) (1999) 29 - 30.A. B. Kay, "T cells in allergy and anergy," Allergy, vol. 54, no. s56, pp. 29-30, Oct. 1999.Kay, AB (1999) T cells in allergy and anergy. Allergy 54: pp. 29-30...
Furthermore, it is noticeable that Tregs likely contribute to allergic disorders such as dermatitis and airway inflammation, and play a crucial role in the treatment of allergy through their actions on suppression of effector T cells and inhibition of activation of mast cells and basophils. ...
Restricted deletion of CD39 in endogenous CD8+ T cells resulted in slowed tumor progression, improved immunotherapy responsiveness and enhanced infiltration of transferred tumor-specific T cells. CD39 is induced on tTex cells by tumor hypoxia, thus mitigation of hypoxia limits tTex suppression. ...
Regulatory T cells have been shown to have massive infiltration of a variety of solid tumors in humans and mice as well as increased cellular levels in the peripheral blood. Questions 1. What changes occur in the number and function of Treg cells in patients with multiple myeloma?
reached to change the cellular metabolic pathways (Fig. 1). The intracellular adaptations that occurred in T cells to cope with changing oxygen levels are especially unclear. However, it may be said with certainty thatT cell signalling, metabolism and function are influenced by such environmental ...
T cells in drug allergy In recent years, increasing evidence has indicated an important role for T cells in various drug-induced diseases. A detailed analysis of patients with var... WJ Pichler - 《Curr Allergy Asthma Rep》 被引量: 66发表: 2002年 ...
The proliferative response of T lymphocytes when cocultured with autologous non-T cells in the absence of any other stimulating substance has been termed t... GW Canonica,R Croci,M Bagnasco,... - 《Int Arch Allergy Immunol》 被引量: 13发表: 1984年 HLA matching donor-originating activated ly...