A molecule or molecule complex capable of binding to TLR9 and to CD32 comprising at least one epitope of at least one antigen, and its use a medicament for the treatment of allergies.Mudde, GeertHimmler, Gottfried
Gut Microbiome Proteomics in Food Allergies 2023, International Journal of Molecular Sciences Immunoregulatory T cell epitope peptides for the treatment of allergic disease 2021, Immunotherapy Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods 2016, Allergy: European Journa...
...as a treatment “...It is involved in the regulation of allergies, as well as a signaller for T-cell regulation...” Immune System Imbalance (TH2 Dominance) ...the condition “...While cellular immunity (Th1) directs Natural Killer T-cells and macrophages to attack abnormal cell...
various non-surgical treatments for liver metastasis, such as ablation, chemotherapy, radiotherapy, and immunotherapy, exist; however, their efficacy is often constrained. Consequently, the pursuit of improved and safer treatment approaches has become increasingly imperative. ...
birth in children who subsequently develop food allergy9, and are related to pro-inflammatory neonatal immune responses that persist into early infancy10. Attenuated T cell signaling11and regulatory T cell (Treg)-suppressive function12have also been reported among neonates that acquire food allergies ...
T cells, one of the most heterogeneous and versatile immune populations, are the instrumental force in eliciting adaptive immunity for either providing a long-term immunological protection against canceration[1]and infectious diseases[2]through the specific effector cells-mediated targeted cells-killing ...
Manufacturing CAR cell therapy in the traditional way has several hurdles. The process itself is lengthy, taking up to 22 days and requiring specialized labs, which significantly inflates the cost and potentially delays treatment for patients in urgent need [58]. Furthermore, Isolating cells can ...
and allergies [82]. CTLs are considered the primary effector cells responsible for direct TC killing and are a vital component of anti-tumor immunity [83]. The balance between CD4+and CD8+T lymphocytes is crucial for maintaining normal immune function. Disruption of the ratio between these two...
Collected data from several clinical trials evaluating the efficacy of recombinant IL-2 therapy in the 1980s showed that a small fraction of melanoma patients experienced durable complete responses. Based on these results, in 1998, the FDA approved IL-2 for the treatment of unresectable melanoma [...
T-lymphocytes) is predominant; it is responsible for resistance to infectious diseases caused by certain bacteria, fungi, and viruses, certain aspects of resistance to cancer, delayed hypersensitivity reactions, certain autoimmune diseases, and allograft rejection, and plays a role in certain allergies....