A molecule or molecule complex capable of binding to TLR9 and to CD32 comprising at least one epitope of at least one antigen, and its use a medicament for the treatment of allergies.Mudde, GeertHimmler, Gottfried
The concept that CD28 is involved in the proliferation of memory T cells is intriguing in the light of recent data related to checkpoint blockade for cancer treatment. It has been suggested that PD-1 blockade, which is important to the reinvigoration of exhausted effector T cells, requires CD28...
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In contrast to the proinflammatory phenotype of Th cells, Treg cells participate in the prevention of uncontrollable inflammatory responses, autoimmune diseases and allergies by suppressing T effector (TEFF) cells and other immune cells9. Treg cells are defined by the expression of the forkhead box ...
Featured on this page Chapters and Articles You might find these chapters and articles relevant to this topic. Pathological role of LncRNAs in immune-related disease via regulation of T regulatory cells Sulieman Ibraheem Shelash Al-Hawary, ... Mays Jassim abdalkareem, in ...
Although representing an intriguing new concept, only few attempts to treat allergic diseases with peptide immunotherapy are reported as of today, among them allergies to cat hair, ragweed and bee venom. One of the reasons for the still limited use and application of peptide immunotherapy lies in...
with no plans for pregnancy within 6 months of treatment. Patients with mental or psychological illnesses, severe allergies, or a history of severe allergies (especially those who were allergic to interleukin 2[IL-2]) were excluded. Detailed criteria for inclusion and exclusion are provided in sup...
A combination of genetic and environmental factors is likely to be responsible for the increased prevalence of both allergic and autoimmune diseases. Whilst the majority of approaches towards treatment are palliative, specific allergen immunotherapy (SIT) is an approach that has been proven to be ...
and allergies [82]. CTLs are considered the primary effector cells responsible for direct TC killing and are a vital component of anti-tumor immunity [83]. The balance between CD4+and CD8+T lymphocytes is crucial for maintaining normal immune function. Disruption of the ratio between these two...
coryza, hay fever, bronchial asthma, urticaria (hives) and food allergies, and other atopic conditions. The method is accomplished in the same way as described above for cancer and infectious disease, except that the immune response is elicited towards an antigen that is specific for an allergen...