TCRVbeta21/Jbeta2.7 expansion was also observed in IL-2-stimulated TIL cell lines and was confirmed by sequencing analysis of the V-D-J junctional region. These results strengthen the view that local antigen-driven selection may occur, and support the hypothesis that anti-tumor immune response...
Compre- hensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing. Sci Rep 2015;5:10092.Li Z, Liu G, Tong Y, Zhang M, Xu Y, Qin L, et al. Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high ...
Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a STEAP1-directed chimeric antigen receptor (CAR) T cell therapy. STEAP1 CAR T cells demonstrate reactivity in low antigen density, ...
Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or refractory B-cell hematologic malignancies. However, CAR-T-cell therapy has not yet achieved comparable success in the management of aggressive T-cell malignancies. This article...
The status of CD13,47 CD26, CD49d, and CD60 antigens91-93 and the possible role of T-cell receptor V-beta repertoire analysis51,53 requires further study at this time. Based on the literature reviewed herein, the proceedings of the ISCL meetings in Zurich, Napa, Bethesda, New Orleans...
Thus, we sought to determine whether negative co-stimulation has a functional role in both T cell activation as well as differentiation. CD28 is the primary source of positive co-stimulation and represents a critical second signal for T cell activation after T cell receptor (TCR) engagement (...
T-cell receptor (TCR) sequencing detects considerable inter-individual transcriptomic heterogeneity in the dominant T cell clone Both in patch and plaque/tumor lesions, T cells represented the largest fraction of cells (Fig.1C, Table S1). Most of the nine individual T-cell clusters were found ...
f, Percentages of TCRVβ5+, Vβ6+ and Vβ8+ cells among the indicated splenic CD4 T cell populations from 8–10-week-old female Foxp3LSL/DTR–GFP mice. Cells are gated on the CD44loCD62Lhi subset to avoid potential clonal expansion during activation. One-way ANOVA. g, 2×106 CD...
Here we used T cell receptor beta variable chain (TCRBV) spectratyping and/or TCRBV sequencing to monitor the specific TCR usage in eleven HA-1/HA-2 CTLs that were induced ex vivo with peptide pulsed dendritic cells. The HA-2 induced CTLs used different TCRBV. In contrast, the ...
The present invention is directed to the field of immunotherapy, in particular, adoptive T cell therapy or T cell receptor (TCR) gene therapy of cancer, in particular, of B cell lym