Definition There are two types of T-cell receptors (TCR), defined as α:β or γ:δ TCRs. The receptor for antigen on most T cells, the α:β T-cell receptor, is composed of two protein chains, T-cell receptor α and T-cell receptor β, and resembles in many respects a single ...
Medical Definition T cell receptor noun variantsorT-cell receptor :an antigen receptor on the surface of aT cellthat is composed of two transmembrane polypeptide chains covalently linked by disulfide bonds and that initiates T cell activation upon binding with a specific antigenic peptide fragment combi...
T-Cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-Cell Receptor) is a complex of integral membrane proteins that participates in the activation of T-Cells in response to the presentation of antigen.
Browse Nearby Words TCE T cell T cell receptor See all Nearby Words Cite this Entry Style “T cell.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/T%20cell. Accessed 11 May. 2025. Copy Citation ...
T CELL RECEPTORS The T cell receptor (TCR) is a T cell surface structure that is comprised of a disulfide-linked heterodimer of highly variable α and β chains expressed at the cell membrane as a complex with the invariant CD3 chains. Most T cells that bear this type of receptor are ter...
The T cell receptor signalosome integrates multiple positive and negative regulatory elements to finetune the response and limit harmful inflammation. Here authors show a regulatory cascade of T cell activation, in which DUSP22 negatively regulates UBR2, which is an activator of the kinase Lck via...
T-cell receptor articles from across Nature Portfolio Atom RSS Feed T-cell receptors (TCRs) recognize small protein fragments (peptides) that are displayed on the surface of antigen-presenting cells. Each T cell expresses a unique TCR that is generated by randomly assorting genes. This ensures...
1.2 T cell and its subsets T cells play a crucial role in the eradication of pathogens and the scrutiny of pathological cells. T cells are of two major subsets founded on their unique T cell receptor (TCR) chain, cytokine expression profile, and co-receptor expression. Based on TCR, they...
T 细胞受体(T cell receptor,TCR)是 T 细胞表面重要的分子结构,对于 T 细胞识别抗原、激活免疫反应等过程至关重要。 T 细胞受体通常由两条不同的肽链组成,即α 链和 β链(约 95% 的 T 细胞),少数情况下由 γ 链和 δ 链组成(约 5% 的 T 细胞)。每条链都包含一个可变区(V 区)和一个恒定区(C ...
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes ...