splenomegaly, and bone marrow (BM) infiltration in 16 adults, which was differentiated from cutaneous T-cell lymphoma [1]. The association of ATLL and human T-cell lymphotropic virus (HTLV)-1 virus was discovered because all patients have antibodies against the virus, which corresponded...
Adult T-cell leukemia/lymphoma, an aggressive T-cell neoplasm, is causally linked to human T-cell lymphotropic virus type 1 and based on this association has a distinct geographic distribution. In our United States-based practice, whose population is enriched for immigrants from human T-cell lymp...
Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols Article Open access 14 May 2024 Allogeneic hematopoietic stem cell transplantation overcome the poor prognosis of patients with IKZF1plus CD20–a very high-risk subtype in B-cell...
The prognosis of adult T-cell leukemia/lymphoma (ATL) with primary central nervous system (CNS) involvement has been unclear since the advent of new therapies. Recently, we have shown that flow cytometric CD7/CADM1 analysis of CD4+cells (HAS-Flow) is useful to detect ATL cells that are ...
The antiapoptotic effects of this pathway are mainly mediated through the suppression of downstream B-cell CLL/lymphoma 2 (BCL2) expression [104], whereas IL7-induced cell cycle progression requires downregulation of p27. Two independent studies described somatic gain-of-function mutations in IL7R ...
Non-ALCL T-cell lymphoma remained significant, thereby allowing it to be considered as an independent adverse prognostic factor. The poor prognosis of peripheral T-cell lymphoma has been reported in most series.2351138 With the intensive regimens used in the LNH87 study, the 41% 5-year survival...
Adult T cell leukemia/lymphoma (ATL) is a highly aggressive T cell malignancy, and has a poor prognosis. Recently, allogeneic-hematopoietic stem cell trans... S Shiratori,A Yasumoto,J Tanaka,... - 《Biology of Blood & Marrow Transplantation Journal of the American Society for Blood & Marrow...
Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in our knowledge of the causes for MCL and available treatments for MCL, this cancer ...
Mature T cell lymphoma has been noted for poor prognosis when compared with B cell lymphoma, even in the pre-rituximab era. To confirm this difference, a retrospective cohort study was conducted. One hundred-and nineteen patients with mature T cell lymphoma and 568 patients with diffuse large ...
A CAR targeting the TCR-β chain constant-domain 1, that leaves normal T cells expressing TRBC2 unaffected, is currently under test in a clinical trial including mature T-cell non-Hodgkin lymphoma (no. NCT03590574). However, this CAR is not suitable for T-ALL because only a minority ...