T cell lineage commitment是指T细胞在分化过程中失去全能性，并获得特定发育命运的过程。以下是关于T细胞谱系决定的几个关键点：细胞分化：T细胞谱系决定是T细胞分化的一个关键阶段。在这个过程中，未成熟的T细胞逐渐分化为具有特定功能和特性的成熟T细胞亚群。失去全能性：在T细胞谱系决定之前，未成熟的T细胞具有向
The present results clearly showed that RBP-J-mediated Notch signaling is dispensable for the lineage commitment, survival, and maturation of CD4/CD8 T cells. Regulation of Peripheral T Cell Functions by Notch/RBP-J Signaling In the absence of RBP-J, Th2-dependent isotype production was ...
aFigure 1. T Helper Cell Lineage Commitment and Microenvironmental Location 图1。 T协助细胞后裔承诺和Microenvironmental地点[translate] aAntarctic Intermediate Water (AAIW) originates from subduction along the Polar Front.[translate] a现在我在住宅小区管理处 Now I in residential district administrative of...
3. Lineage commitment: Commitment of thymocytes to effector cell lineages, including CD4 helper or ...
科大讯飞翻译(iFLYTEK Translation)Abstract T lymphocytes (T cells) play an important role in adoptive cellular immunotherapy (ACT). T cells can be stably derived and easily obtained by various methods of T cell development in vitro, which have more advantages than traditional methods of T cells is...
Late pre-T cells (CD25−CD44−), which had traversed the β-selection checkpoint, expressed surprisingly heterogeneous surface levels of the pre-TCR: high levels of surface pre-TCR expression were associated with commitment to the αβ T-cell lineage, whereas late pre-T cells with lower ...
主要研究方向为免疫细胞(特别是T细胞)发育、分化和功能,以及蛋白翻译后修饰和信号传导通路在这些过程中的作用。先后获得“千人计划”青年项目、国家重点研发计划干细胞专项、蛋白质机器专项和国家自然科学基金委等项目的支持。研究论文以第一/通...
8. Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, et al. cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc...
After positive selection and lineage commitment, the TCRαβ+CD4/CD8 SP medullary thymocytes migrate into and reside in thymic medulla, where they undergo an ordered program of late stage of T cell functional maturation and negative selection to delete self-reactive clones by apoptosis. Accomplishme...