T cell lineage commitment是指T细胞在分化过程中失去全能性，并获得特定发育命运的过程。以下是关于T细胞谱系决定的几个关键点：细胞分化：T细胞谱系决定是T细胞分化的一个关键阶段。在这个过程中，未成熟的T细胞逐渐分化为具有特定功能和特性的成熟T细胞亚群。失去全能性：在T细胞谱系决定之前，未成熟的T细胞具有向
5. Sebastian J, Arnold., Elizabeth J, Robertson.(2009). Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo.Nat Rev Mol Cell Biol, 10(2), 0. doi:10.1038/nrm2618 6. Lila, Solnica-Krezel., Diane S, Sepich.(2012). Gastrulation: making and shaping...
Cell shape regulated the switch in lineage commitment by modulating endogenous RhoA activity. Expressing dominant-negative RhoA committed hMSCs to become adipocytes, while constitutively active RhoA caused osteogenesis. However, the RhoA-mediated adipogenesis or osteogenesis was conditional on a round or ...
"Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment." Cell Metabolism 36(3): 466-483.e467. (20240123,中国药科大学,郝海平,郑啸,王广基;东南大学,袁勇贵)通过多学科技术手段,揭示了精神应激...
Here we integrated flow cytometric, transcriptomic and functional data at single-cell resolution to quantitatively map early differentiation of human HSCs towards lineage commitment. During homeostasis, individual HSCs gradually acquire lineage biases along multiple directions without passing through discrete ...
Inactivation of RBP-J in the DN4 stage showed no abnormalities in CD4/CD8 lineage commitment but enhancement of Th1 responses and reduction in T cell proliferation. Results Intrathymic Deletion of RBP-J by lck-cre or CD4-cre In order to assess the functions of RBP-J in T cell development,...
We have shown that expression of a chimeric CD8/CD4 transgene can alter T cell lineage commitment such that cells expressing a transgenic class I major histocompatibility complex-restricted T cell receptor can differentiate to the CD4 rather than those the CD8 lineage. The implications of these ...
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell sign
Psychological stress-induced microbial metaboliteindole-3-acetatedisrupts intestinal cell lineage commitment Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells ABCG2 is an itaconate exporter that limits antibacterial innate immunity by...