原文摘要(Abstract) T cell acute lymphoblastic leukemia (T-ALL) is difficult to treat when it relapses after therapy or is chemoresistant; the prognosis of patients with relapsed or refractory T-ALL is generally poor. We report a case series of 17 such patients who received autologous chimeric ...
The malignancy, arising after the long carrier phase, may be manifested as a lymphoma or acute leukemia, with high white blood cell count and a poor prognosis, usually being fatal within 6–8 months. Smoldering and chronic forms of ATL can convert into an acute course. Approximately 3% of ...
Method for estimating prognosis adult T-cell leukemia-lymphoma and kitsPROBLEM TO BE SOLVED: To provide a method for preparing data for providing prognosis-estimating data usable for estimating ATLL prognosis, specifically, estimating possibility of HTLV-I carrier outbreak, forecasting progression to ...
To specifically address the impact of high-level TCL1A on TCR responses, we used T-cell leukemia lines (HH, Hut78, and Jurkat) that were modified to constitutively or inducibly express a TCL1A transgene resulting in protein levels similar to those of human T-PLL (supplemental Figure 8A) and...
B-cell maturation antigen BM : bone marrow CA : cytogenetic abnormalities CAR : chimeric antigen receptor CI : confidence interval Cilta-cel : ciltacabtagene autoleucel CLL : chronic lymphoid leukemia CR : complete response CRS : cytokine release syndrome CZ : Changzheng Hospital ...
ATXN1 or CIC alterations are present in 53% of adult T-cell leukemia/lymphoma (ATLL) cases, and CCR4 (C–C chemokine receptor 4) mutations are common, and the majority of ATLL patients exhibit CCR4 overexpression, which is associated with skin involvement and worse prognosis [32]. 9p24 ...
急性髓系白血病(AcuteMyeloid LeukemiaAML)是一种造血系统恶性克隆增殖性疾病。AML常与特定的染色体以为及相关的融合蛋白相关,在2016年世界卫生组织(WorldHealth OrganizationWHO)造血与淋巴组织肿瘤分类分型中,伴有t(6:9)(p23:q34)-DEK-NUP214融合基因的急性髓系白血病,是髓系血液系统恶性肿瘤中较为罕见的,其阳性率...
J. Yeoh 1,2,3,8 & Dario Campana 2,3,8T cell acute lymphoblastic leukemia (T-ALL) is dif f i cult to treat when it relapses after therapy or is chemoresistant; the prognosis of patients with relapsed or refractory T-ALL is generally poor. We report a case series of 17 ...
“Peripheral T cell lymphoma is an aggressive subset of non-Hodgkin’s lymphoma typically associated with a poor prognosis,” Richard A. Miller, MD, co-founder, president, and chief executive officer of Corvus, stated in a news release.1“For these patients, there is significant need ...
Spontaneous remission of large granular lymphocyte T cell leukemia. Presents a case study on spontaneous remission of large granular lymphocyte (LGL) T cell Leukemia. Rearrangement of the T cell receptor gene; Features of l... M Takeuchi,A Tamaoki,R Soda,... - 《Leukemia Official Journal of ...