A major mechanism by which human regulatory T cells (T-reg) have been shown to suppress and kill autologous immune cells is through the granzyme-perforin pathway. However, it is unknown whether T-regs also possess the capacity to kill tumor cells using similar mechanisms. Bispecific antibodies ...
Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we demonstrate that T cells expressing TCRs specific for peptides from the intracellular lymphoid
[Key words]Engineered T cell receptor-T cell; Immunotherapy; Solid tumors; Tumor antigens; Chimeric antigens receptor-T cell 过继性T细胞治疗(adoptive T cell therapy,ACT)策略已成为癌症治疗的主要方式。T细胞受体工程T细胞(engineered T cell receptor-T ce...
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy Article 06 December 2021 PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes Article 21 March 2024 Introduction T cells possess superior ability to kill tumor cells1. This killing process occu...
T细胞杀伤实验测试(T cell Killing Assay) 东大生物的T细胞杀伤测定法可鉴定受测品在促进或抑制T细胞活性后对靶肿瘤细胞杀伤/变态反应作用的影响程度。 这一方法可用于抗体受测品,如双特异性抗体(bscAb),特别是双特异性T细胞衔接子(BiTE)子类的抗体。 最终,将
tumor antigen, called neoantigens, and then kill tumor cells that present these neoantigens. The neoantigens mainly arise from the DNA mutations found in tumor cells. These mutations are translated into mutated proteins that are then distinguished by T cells. In this article, we discuss the ...
The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysing the TCR repertoire may help to gain a bette
T cell-mediated antitumor effects by chimeric antigen receptors. T cells are activated and can kill tumor cells by secreting granzymes and perforin, as well as the expression of TRAIL and FasL. Moreover, immune cells that invade the tumor can be activated by secreting various cytokines Full siz...
Cell death plays two major complementary roles in T cell biology: mediating the removal of cells that are targeted by T cells and the removal of T cells themselves. T cells serve as major actors in the adaptive immune response and function by selectively killing cells which are infected or ...
【and the absence of tumor-specific T-cell recognition and cytotoxicity .】在 B2M 基因敲除小鼠肺癌模型中观察到了相同的【Identical完全相同的】结果,该模型显示出对 PD-1 阻断的抗药性。此外,溶酶体途径【lysosomal pathway】与 CD8+ T 淋巴细胞浸润减...