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Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and viral infections. They are ‘first responders’ that can spontaneously recognize abnormal cells in the body, rapidly eliminate them through focused cytotoxicity mechanisms and potently produce pro-inflammatory cytok...
To evaluate the expression of CD1d and the susceptibility to invariant natural killer T (iNKT) cells in gastric cancer.The expression of CD1d was examined in gastric cancer. The in vitro and in vivo cytotoxic activities of iNKT cells were evaluated against gastric cancer cell lines.CD1d was expr...
InvariantNaturalKillerTCells forCancerImmunotherapy by DrakeJohnSmith DoctorofPhilosophyinMolecularBiology UniversityofCalifornia,LosAngeles,2017 ProfessorDonaldBarryKohn,Chair Cancerimmunotherapyisarapidlydevelopingfieldthathasalreadyshowntobeof greatclinicalvalueasevidencedbythesuccessofengineeredTcelltherapies,suchas...
Named for their capability of killing target cells autonomously, natural killer (NK) cells serve as the main effector cells toward cancer in innate immunity and are highly heterogeneous in the microenvironment. Most current treatment options harnessing the tumor microenvironment focus on T cell-immunity...
Adoptive transfer of antitumor lymphocytes has gained intense interest in the field of cancer therapeutics over the past two decades. Human natural killer (NK) cells are a promising source of lymphocytes for anticancer immunotherapy. NK cells are part of the innate immune system and exhibit potent ...
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly valuable treatment option for cancer and has recently emerged with hundreds of clinical trials paving the way to ...
cancer recurrence [3,4,5]. Treatment of these cancers can reduce physical strength and impair immune response, which can lead to recurrence as well as metastasis of remaining tumor cells in the body after treatment. Therefore, scholars should urgently uncover novel strategies for eliminating these ...