Immunotherapies, specifically immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1(PD-L1), provided a significant advance in cancer treatment [1]. CAR-T cell therapy is a novel form of immunotherapy that employs genetic engineer...
The structural basis of T-cell receptor (TCR) activation: an enduring enigma. J. Biol. Chem. 295, 914–925 (2020). Article PubMed Google Scholar Mardi, A. et al. Biological causes of immunogenic cancer cell death (ICD) and anti-tumor therapy; combination of oncolytic virus-based ...
TableCell>.GetEnumerator Method (System.Windows.Documents) PROPID_MGMT_QUEUE_MESSAGE_COUNT PROPID_MGMT_QUEUE_EOD_LAST_ACK Notifications Notifications Notifications Notifications Visual Basic Code Example: Time Sent Filters INameSpaceTreeControlCustomDraw What's New in Message Queuing 4.0 System-Generated ...
有病例表明PTX诱导免疫原性细胞死亡(ICD)以促进淋巴细胞的浸润并增强抗肿瘤作用,但肿瘤表面表达的PD-L1抑制了浸润性T细胞的活性,因此,需要设计一种精准的药物递送系统来减少肿瘤的副作用并放大药物诱导的抗肿瘤免疫反应。 一篇题目为“Sequential Targeting ...
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Chimeric antigen receptor (CAR) T-cell therapy is a promising and rapidly expanding therapeutic option for a wide range of human malignancies. Despite the ongoing progress of CAR T-cell therapy in hematologic malignancies, the application of this therape
期刊:Cell Stem Cell 影响因子: 23.9 中科院分区: 生物 1区 DOI: 10.1016/j.stem.2024.02.003 摘要:为了改善CAR-T 细胞的效应功能,Zhao 等人 1 报道称,IL-10 可通过代谢重新编程 CAR-T 细胞,从而提高其对抗实体瘤的有效性,并挑战 IL-10 仅具有免疫抑制作用的认知。这种简单但有前途的策略可以培养...
Tocilizumab (Actemra, Genentech) — FDA approved for CRS based on a retrospective analysis of pooled outcome data — is frequently used but has no ICD-10 code for CRS, Farnia said. “When entirely new services are created, codes often need to be created along with them,...
一篇题目为“Sequential Targeting Hybrid Nanovesicles Composed of Chimeric Antigen Receptor T-Cell-Derived Exosomes and Liposomes for Enhanced Cancer Immunochemotherapy”的文章报道了利用CAR-T细胞衍生的外泌体与肺靶向脂质体融合的杂交纳米囊泡来递送PTX来治疗肺癌的潜在有效策略。CAR-T细胞衍生的外泌体包含肿瘤靶向...
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