Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, wh
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有病例表明PTX诱导免疫原性细胞死亡(ICD)以促进淋巴细胞的浸润并增强抗肿瘤作用,但肿瘤表面表达的PD-L1抑制了浸润性T细胞的活性,因此,需要设计一种精准的药物递送系统来减少肿瘤的副作用并放大药物诱导的抗肿瘤免疫反应。 一篇题目为“Sequential Targeting ...
1. Idecabtagene vicleucel chimeric antigen receptor T-cell therapy for relapsed/refractory multiple myeloma with renal impairment 译：Idecabtagene vicleucel 嵌合抗原受体 T 细胞治疗肾功能不全的复发/难治性多发性骨髓瘤 作者列表:Sidana S;Peres LC;Hashmi H;Hosoya H;Ferreri C;Khouri J;Dima D;Atra...
All subpopulations transcribed TCR genes from all four cassettes, although there were differences in expression levels. Finally, the CD2+ and CD2−γδ T-cell populations differed in their representation in various organs and tissues, presumably at least partially reflective of different ligand ...
In ESS mice, CD19+CD1dhiCD5+ Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation. Consistently, CD19+CD24+CD38hi Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the ...
Apoptosis, pyroptosis, necroptosis, ferroptosis, and autophagy-dependent cell death are among the cell death pathways identified thus far, all of which are categorized as ICD [18,19,20]. Apoptosis is a kind of non-inflammatory programmed cell death that may be triggered by either intrinsic or ...
一篇题目为“Sequential Targeting Hybrid Nanovesicles Composed of Chimeric Antigen Receptor T-Cell-Derived Exosomes and Liposomes for Enhanced Cancer Immunochemotherapy”的文章报道了利用CAR-T细胞衍生的外泌体与肺靶向脂质体融合的杂交纳米囊泡来递送PTX来治疗肺癌的潜在有效策略。CAR-T细胞衍生的外泌体包含肿瘤靶向...
PTEN基因在T-ALL细胞株JURKAT中的作用以及对NOTCH1,C-MYC基因调控机制研究 目的:T淋巴细胞白血病(T-cell acute lymphoblastic leukemia, T-ALL)是来源于T淋巴细胞的恶性克隆性肿瘤,发病率约占儿童ALL的10%-15%,占成人ALL的25%.T-ALL的发病机制... 李智慧 - 《河北医科大学》 被引量: 1发表: 2012年 Notch...
Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells (PSCs) is a central aim in T cell regenerative medicine. To date, preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge. He