Conclusion Vpx allows the non-productive infection of resting CD4+ T cells, but does not confer HIV-2 with the ability to efficiently infect MDDCs. In these cells, an entry defect prevents viral fusion and reverse transcription independently of SAMHD1. We propose that HIV-2, like HIV-1, ...
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation The latent reservoir of HIV-1 in resting memory CD4+ T cells is a major barrier to curing HIV-1 infection. Eradication strategies involve reactiv...
名称:EasySep™ 人静息CD4+T细胞分选试剂盒 品牌:STEMCELL 产品描述:Immunomagnetic negative selection kit 购买数量: 立即购买 产品信息 The EasySep™ Human Resting CD4+ T Cell Isolation Kit is designed to isolate resting CD4+ T cells from fresh or previously frozen human peripheral blood mononuclear ...
1 infection can persist despite ART in the resting CD4⁺ T cell reservoir of hu-Rag2⁻/⁻ γ(c)⁻/⁻ mice. This model will allow rapid preliminary assessments of novel eradication approaches and combinatorial strategies that may be challenging to perform in the NHP model or in humans...
resting CD4 T cells HIV-1 nuclear import Vpx Research topic(s) CP: Immunology CP: Microbiology Introduction CD4 T cells are the major targets of HIV-1 in vivo, and their permissivity to productive infection is dictated by their activation state. The CD4 T cell repertoire residing within lymph...
Resting human CD4 T cells are highly resistant to transfection or infection with lentiviral vectors derived from the human immunodeficiency virus. We now describe a flexible and efficient approach involving virus-like particles containing simian immunodeficiency virus lentiviral gene product protein X and ...
Apoptosis induced in HIV-1-exposed, resting CD4+ T cells subsequent to signaling through homing receptors is Fas/Fas ligand-mediated. induced in HIV-l-exposed, resting CD4+T cells subsequent tO signaling through homing receptors iS Fas/Fas ligand.mediated-J Leukoc BioI 2007;8 1 f1):... Jia...
This might be due to distinct efficiencies of nuclear and cytoplasmic exchange among different cell types, given that Vpx-mediated SAMHD1 degradation is dependent on its nuclear export [11]. Furthermore, Vpx increases HIV-1 infection of all resting CD4+ T-cell subsets (naïve, central memory ...
Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+