ATLG给药前淋巴细胞减少影响MUD allo-PBSCT患者移植后结局 英文标题:Lymphopenia but not Absolute Lymphocyte Count before ATLG Administration Impacts Transplant Outcomes in Matched Unrelated Peripheral Blood Stem Cell Allogeneic Stem ...
The meaning of ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA is an uncommon and often fatal non-Hodgkin lymphoma that arises from T cells and is characterized especially by fever, weight loss, enlarged lymph nodes, night sweats, skin rash, and the proliferation of
T-cell culturePeripheral blood mononuclear cells (PBMCs) can be used to assess cell-mediated immunity in general or via antigen-specific stimulation to detect previous exposure to a variety of antigens/allergens and to monitor the response to immunotherapies. Peripheral blood is the most common ...
What Is a Naïve Cell?Lymphocytes are a type of white blood cell that carry out effector functions against foreign particles that could cause an infection. They play an integral role in human adaptive immunity due to their antigen-specificity. ...
[11] Transplant Cell Ther.2024 Mar 7:S2666-636(24)00253-7. [12] Shah N, et al. ASH 2021, Blood 2021; 138:1739. [13] Blood. 2021;137(21):2890-2901. 审校:Cherry 排版:Cherry 执行:Quinta 本平台旨在为医疗...
The mechanism of gut microbiome and blood metabolites regulate the TME in multiple myeloma (MM) remain unclear. Here the authors showLachnospiraceaecan suppress MM cell phosphatidylcholine (PC) production, with the latter inhibiting CD8 T cell function via TP53 UFMylation elicited by exosomal Serpin...
患者群体特征:纳入的 283 例患者中位年龄 66 岁,弥漫性大 B 细胞淋巴瘤未另行分类(Diffuse Large B - cell Lymphoma Not Otherwise Specified)占比 77% 。CAR - T 治疗后,总体缓解率(Overall Response Rate,ORR)为 80%,完全缓解(Complete Response,CR)率为 64% 。2 年无进展生存期(Progression - Free Su...
peripheral blood mononuclear cell TCR: T-cell receptor TEMRA: effector memory T-cells re-expressing CD45RA References Muller L, Fulop T, Pawelec G. Immunosenescence in vertebrates and invertebrates. Immun Ageing. 2013;10:12. Article PubMed Central PubMed Google Scholar Linton PJ, Dorshkind...
T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we
An active involvement of blood-brain barrier endothelial cell basement membranes in development of inflammatory lesions in the central nervous system (CNS) has not been considered to date. Here we investigated the molecular composition and possible function of the extracellular matrix encountered by extra...