Once a naive B cell recognizes its target antigen, they form germinal centers with the help of CD4 helper T cells. In the germinal center early stage antibody-secreting B cells undergo isotype switching and transition into a plasma cell. Antibody production by B cells can quickly neutralize a...
(through HEVs in the outer paracortex), moving centripetally into the T cell area, which fans out beneath B cell follicles16,17. Notably, in uninfected mice, CD8a+ DCs are found in this region, and these cells have been suggested by ex vivo studies to be the only lymph node cell ...
because as autoantigen they do not require cell damage or cell death to be released and are naturally displayed on a 2-dimentional surface essentially spanning the entire follicle (Supplementary information, Fig.S1), a condition very much conducive to B cell activation...
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Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells
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BiTEs are unique in their ability to redirect T-cells against TAAs on tumor cells and directly activate T-cells, independent of TCR/MHC interaction [21]. More specifically, T-cell activation by interaction with the TCR complex engages T-cells to form an immune synapse on the surface of ...
14,24,25 The effectiveness of anti-CD19 CAR T cells against B-cell malignancies encouraged us to develop a CAR T-cell therapy for multiple myeloma. Appropriate target antigens for CAR T-cell therapies should be uniformly expressed on the malignancy to be treated and should not be expressed ...
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