Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the cur...
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic progenitors, and then subjected to endocrin
Current single-cell RNA sequencing (scRNA-seq) methods with high cellular throughputs sacrifice full-transcript coverage and often sensitivity. Here we describe Smart-seq3xpress, which miniaturizes and streamlines the Smart-seq3 protocol to substantially
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(4) Natural penetrability: PDNVs can cross the cell barrier, blood–brain barrier, and skin barrier to protect or repair the tissues [24, 27]. (5) Biocompatibility: PDNVs, derived from natural sources and even part of our daily diet, have low immunogenicity and exhibit good biocompatibility...
Our new solution achieves full-color high-fidelity cell imaging within a working distance of at least 4 mm by only collecting the fiber outputs after an initial calibration. High imaging robustness is also demonstrated when the disordered fiber is bent with a central angle of 60°. Moreover,...
In this section, we summarize the basic principles of main functional modules, including microvalve, micropump, micromixer, separator, droplet generator, gradient generator, trap and cell culture, and analyze their feasibility as the components of modular microfluidics....
Microbial Cell Factories volume 18, Article number: 41 (2019) Cite this article 28k Accesses 9 Altmetric Metrics details Abstract Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non...
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations in unicellular genomes, as well as new cell-specific markers and cell types. scRNA-seq plays...
1): (1) cell type annotation, (2) calculation of SPatially Adjacent Cell type Embedding (SPACE), (3) Jensen–Shannon divergence (JSD)-based hierarchical clustering, and finally (4) multi-slice spatial domain analysis. Fig. 1 Workflow of SpaDo. a Calculating SPACE for both single-cell and...